Research progress on the mechanism of platelet granule release and its effect on specimen preanalytical variation

doi:10.3969/j.issn.1673-8640.2021.05.020

Abstract

Abstract:

Platelet release refers to the process in which activates platelets release their granules（α granules,compact granules and lysosomal granules） and contents into plasma. Over the past 2 decades,the development of antiplatelet drug has led to advances in the study of platelet release mechanisms and their effects on preanalytical variation of clinical specimens. In vitro,platelet release is closely related to preanalytical variation of the specimen. Factors including the material of the blood storage vessel,internal additives,shear stress and storage temperature may induce platelet morphological changes,activation and dysfunction and consequently affect the release of platelet granules and contents. It will lead to preanalytical variation of specimens,and finally influence the results. Therefore,it is necessary to understand the effect of platelet release on preanalytical variation of specimens to improve the accuracy of results.

Key words: Platelet release, Platelet granule, Preanalytical variation

CLC Number:

R446.1

ZHANG Shihong, FANG Bangren, YE Manman, DENG Guanhua. Research progress on the mechanism of platelet granule release and its effect on specimen preanalytical variation[J]. Laboratory Medicine, 2021, 36(5): 560-564.

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