Abstract:

Objective To investigate the roles of serum amyloid A（SAA）combined determination with C-reactive protein（CRP） and blood routine test in the diagnosis of corona virus disease 2019（COVID-19）. Methods Totally,30 patients with COVID-19 in Xiangyang Central Hospital were enrolled as COVID-19 group,and 33 healthy subjects were enrolled as control group. The results of blood routine test and CRP and SAA determinations and their clinical data were collected and analyzed between the 2 groups. Results Compared with control group,body temperature,the percentage of neutrophil（NEUT%）,CRP and SAA in COVID-19 group were increased,and the percentage of lymphocyte（LYMPH%） was decreased（P<0.01）,but white blood cell（WBC） count had no statistical significance（P>0.05）. The positive rate of SAA in the diagnosis of COVID-19 was 93.3%. When the opitmal cut-off value of SAA was 6.43 mg/L,the sensitivity was 100%,and the specificity was 91.9%. The area under receiver operating characteristic（ROC） curve（AUC） was 0.994. The AUC,sensitivity and specificity of SAA for different computed tomography（CT） stages were 0.851,82.4% and 76.9%,respectively,and SAA in different CT stages had statistical significance（P<0.01）. Conclusions Hematological indexes,especially SAA,can diagnose COVID-19 rapidly and accurately,which can provide a reference for clinical treatment.

Key words: Corona virus disease 2019, Serum amyloid A, C-reactive protein, Blood routine test