Abstract:

Objective To analyze the clinical characteristics and drug resistance of Corynebacterium striatum in Henan,and to provide a reference for rational usage of antibiotics. Methods A total of 74 isolates of Corynebacterium striatum were collected in Henan Provincial People's Hospital from 2016 to 2018,and the sample type,department distribution and drug susceptibility test results were analyzed. Results The incidence rate of Corynebacterium striatum infection in Henan showed an increasing trend from 2016 to 2018（χ²=4.196,P=0.041）. The main sample source was sputum（44.6%）. The main department was intensive care unit（31.1%）. There were 60 cases（81.1%） with underlying diseases,while 65 cases（87.7%） underwent invasive manipulation. Drug susceptibility test showed that these isolates had high resistance rates to penicillin,ciprofloxacin and clindamycin（the drug resistance rates >90%）,but they had low resistance rates to vancomycin and linezolid（the drug resistance rates were 0% and 2.7%,respectively）. Conclusions The infection rate of Corynebacterium striatum in Henan is increased with a relatively high detection rate of non-respiratory samples. The drug susceptibility is regionally specific,so that it should pay more attention on them.

Key words: Corynebacterium striatum, Infection, Drug resistance, Henan province