Research progress of human serum transferrin glycosylation

doi:10.3969/j.issn.1673-8640.2019.06.020

Abstract

Abstract:

Transferrin is one of high abundance glycoproteins in serum,which has become the research focus because of its special physiological function. Its multiple functions include antimicrobial activity,nourishing cells,growth and differentiation activities as the researches of its function and structure deepened. Transferrin determination has been widely used in the diagnostic evaluation of iron-related disorders. There is a close relationship with the pathophysiologic state of the liver as well. Recently,altered glycosylation of transferrin has been recognized in a variety of diseases,especially in malignancies as with the achievement of glycomics and related technologies. In this review,transferrin and its altered glycosylation as well as its relationship with diseases are introduced.

Key words: Transferrin, Glycoprotein, Glycosylation

CLC Number:

R446.1

GUAN Wenqian, GAO Chunfang. Research progress of human serum transferrin glycosylation[J]. Laboratory Medicine, 2019, 34(6): 563-566.

References 39

[1]	YAN J,GONG X,PAN S,et al.Expression of human transferrin can be regulated effectively by rabbit transferrin regulatory elements in transgenic mice[J]. Biotechnol Lett,2014,36(6):1209-1216.
[2]	SCHADE A L,CAROLINE L.An iron-binding component in human blood plasma[J]. Science,1946,104(2702):340-341.
[3]	PENEZI A,MILJUŠ G,MILUTINOVI B,et al.A microscale protocol for the isolation of transferrin directly from serum[J]. Clin Chim Acta,2017,471:12-16.
[4]	BOMFORD A B,MUNRO H N.Transferrin and its receptor:their roles in cell function[J]. Hepatology,1985,5(5):870-875.
[5]	ELSAYED M E,SHARIF M U,STACK A G.Transferrin saturation:a body iron biomarker[J]. Adv Clin Chem,2016,75:71-97.
[6]	GOMME P T,McCann K B,Bertolini J. Transferrin:structure,function and potential therapeutic actions[J]. Drug Discov Today,2005,10(4):267-273.
[7]	ZHAO H Q,WU H,MENG R,et al.Distribution of serum transferrin,and its associations with metabolic disorders among Chinese:a nation-wide,health and nutrition survey[J]. Mol Nutr Food Res,2015,59(8):1535-1540.
[8]	VAN CAMPENHOUT A,CAMPENHOUT C M,LAGROU A R,et al.Transferrin modifications and lipid peroxidation:implications in diabetes mellitus[J]. Free Radic Res,2003,37(10):1069-1077.
[9]	ABDIZADEH H,ATILGAN A R,ATILGAN C.Mechanisms by which salt concentration moderates the dynamics of human serum transferrin[J]. J Phys Chem B,2017,121(18):4778-4789.
[10]	GOZZELINO R,AROSIO P.The importance of iron in pathophysiologic conditions[J]. Front Pharmacol,2015,6:26.
[11]	ZHANG D L,GHOSH M C,ROUAULT T A.The physiological functions of iron regulatory proteins in iron homeostasis-an update[J]. Front Pharmacol,2014,5:124.
[12]	POWELL L W,SECKINGTON R C,DEUGNIER Y.Haemochromatosis[J]. Lancet,2016,388(10045):706-716.
[13]	MUCKENTHALER M U,RIVELLA S,HENTZE M W,et al.A red carpet for iron metabolism[J]. Cell,2017,168(3):344-361.
[14]	LIN L,PANTAPALANGKOOR P,TAN B,et al.Transferrin iron starvation therapy for lethal bacterial and fungal infections[J]. J Infect Dis,2014,210(2):254-264.
[15]	BRUHN K W,SPELLBERG B.Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections[J]. Curr Opin Microbiol,2015,27:57-61.
[16]	SZÖKE D,PANTEGHINI M. Diagnostic value of transferrin[J]. Clin Chim Acta,2012,413(15-16):1184-1189.
[17]	YOSHIHARA A,FUKATSU M,HOSHI K,et al.Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy[J]. J Biochem,2016,160(2):87-91.
[18]	曾惠琼,扶忠超,黄新民,等. D-二聚体、纤维蛋白原、转铁蛋白水平对类风湿关节炎的临床意义[J]. 检验医学,2017,32(10):883-885.
[19]	ZAITSU J,YAMASAKI T,SAEKI I,et al.Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma[J]. Hepatol Res,2013,44(5):481-490.
[20]	何清波,苏炳华,曾民德,等. 200例慢性肝病患者血清免疫学指标与肝纤维化指标的典型相关分析[J]. 胃肠病学,2001,6(2):82-84.
[21]	宋育林,杨文卓,贾一韬,等. 慢性肝病病理分级、分期与血清学指标关系的初步研究[J]. 胃肠病学,2001,6(2):78-81.
[22]	陶虎,高涛,徐斌. 病毒性肝炎患者血清转铁蛋白临床价值再评价[J]. 临床肝胆病杂志,2004,20(3):148-149.
[23]	STIBLER H.Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed[J]. Clin Chem,1991,37(12):2029-2037.
[24]	YAMASHITA K,KOIDE N,ENDO T,et al.Altered glycosylation of serum transferrin of patients with hepatocellular carcinoma[J]. J Biol Chem,1989,264(5):2415-2423.
[25]	MEHTA R,SUVARNA D,MUSTAFA C P,et al.Role of soluble transferrin receptors study in hepatocellular carcinoma with underlying cirrhosis[J]. Indian J Cancer,2005,42(4):215.
[26]	WANG L,LIANG Y,LI Z,et al.Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721[J]. J Cell Biochem,2007,100(1):230-241.
[27]	李力,杨秉辉,李溪冰,等. 不同肝病病人血清转铁蛋白糖链的变化[J]. 中华肝脏病杂志,1996,4(3):148-150.
[28]	黄勇,蒋波,徐一,等. 用DSA分析血清转铁蛋白诊断肝癌[J]. 上海医科大学学报,1994,39(4):249-252.
[29]	HELANDER A,WIELDERS J,ANTON R,et al.Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin(CDT)[J]. Clin Chim Acta,2016,459:19-24.
[30]	ARNDT T,HACKLER R,MÜLLER T,et al. Increased serum concentration of carbohydrate-deficient transferrin in patients with combined pancreas and kidney transplantation[J]. Clin Chem,1997,43(2):344-351.
[31]	VAN KAMP G J,MULDER K,KUIPER M,et al. Changed transferrin sialylation in Parkinson's disease[J]. Clin Chim Acta,1995,235(2):159-167.
[32]	GORNIK O,GORNIK I,Gasparovi V,et al.Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis[J]. Clin Biochem,2008,41(7-8):504-510.
[33]	PIAGNERELLI M,BOUDJELTIA K Z,NUYENS V,et al.Rapid alterations in transferrin sialylation during sepsis[J]. Shock,2005,24(1):48-52.
[34]	SÖNMEZ H,OZTÜRK Z G,ULUTIN T,et al. Carbohydrate-deficient transferrin and sialidase levels in coronary heart disease[J]. Thromb Res,2000,99(4):311-315.
[35]	张丹,冯流星,王军,等. 高效液相色谱-柱后同位素稀释质谱法定量分析人血清中转铁蛋白及白蛋白[J]. 分析化学,2014,42(2):179-185.
[36]	O'CONNOR B F,MONAGHAN D,CAWLEY J. Lectin affinity chromatography(LAC)[J]. Methods Mol Biol,2017,1485:411-420.
[37]	杨舟,王世东,程磊,等. 基于凝集素芯片的蛋白质糖基化修饰检测方法[J]. 诊断学理论与实践,2015,14(5):455-460.
[38]	DAVE M B,DHERAI A J,UDANI V P,et al.Comparison of transferrin isoform analysis by capillary electrophoresis and HPLC for screening congenital disorders of glycosylation[J]. J Clin Lab Anal,2018,32(1).
[39]	GORNIK O,LAUC G.Enzyme linked lectin assay(ELLA) for direct analysis of transferrin sialylation in serum samples[J]. Clin Biochem,2007,40(9-10):718-723.