Influence of hepatitis B virus Pre-S/S region gene mutation on hepatitis B surface antigen determination

doi:10.3969/j.issn.1673-8640.2018.10.018

Abstract

Abstract:

Hepatitis B surface antigen（HBsAg） is the most commonly used marker for the diagnosis of hepatitis B virus（HBV） infection. In recent years,the mutations in Pre-S/S region of HBV genome and amino acid replacement have received widespread attentions. This review summarizes the reasons for the missed determination of HBsAg for Chinese epidemic HBV-mutant strains,which is crucial for the prevention and surveillance of HBV infection and the safety of blood transfusion.

Key words: Hepatitis B surface antigen, Hepatitis B virus, Gene mutation

CLC Number:

R446.1

HE Chengshan, MA Chenyun, LU Zhicheng. Influence of hepatitis B virus Pre-S/S region gene mutation on hepatitis B surface antigen determination[J]. Laboratory Medicine, 2018, 33(10): 949-953.

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