Research progress of circulating tumor DNA in renal cell carcinoma

doi:10.3969/j.issn.1673-8640.2020.09.023

Abstract

Abstract:

Renal cell carcinoma（RCC） is the 7th most common cancer in the world. Due to the lack of symptoms in early stage,many patients are diagnosed with advanced disease and with poor prognosis. Circulating tumor DNA（ctDNA） is tumor-derived fragment DNA in blood or body fluid,which can reflect entire tumor genome and is easy to obtain. It is potential in tumor diagnosis,prognosis assessment,disease recurrence monitoring,therapeutic effect monitoring and chemotherapy resistance monitoring. Recent studies have shown that ctDNA is also clinically valuable in RCC. This review describes the recent progress in the application of ctDNA in the clinical diagnosis and treatment of RCC.

Key words: Circulating tumor DNA, Gene mutation, Methylation, Renal cell carcinoma, Clinical research

CLC Number:

R446.7

SHI Yue, DONG Dong. Research progress of circulating tumor DNA in renal cell carcinoma[J]. Laboratory Medicine, 2020, 35(9): 952-956.

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