Laboratory Medicine ›› 2022, Vol. 37 ›› Issue (4): 330-335.DOI: 10.3969/j.issn.1673-8640.2022.04.006
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LIU Kai, ZHANG Peiru, XIE Suhong, GUO Lin, LU Renquan()
Received:
2021-11-29
Revised:
2022-01-30
Online:
2022-04-30
Published:
2022-06-07
Contact:
LU Renquan
CLC Number:
LIU Kai, ZHANG Peiru, XIE Suhong, GUO Lin, LU Renquan. Clinical value of the SorCS1 gene promoter methylation determination in patients with colorectal cancer[J]. Laboratory Medicine, 2022, 37(4): 330-335.
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组织类型 | 例数 | SEPT9基因启动子甲基化(ΔΔCt) |
---|---|---|
癌组织 | 17 | 5.170(4.015~5.510) |
癌旁组织 | 17 | 1.210(1.445~2.410) |
Z值 | -3.243 | |
P值 | <0.001 |
组织类型 | 例数 | SEPT9基因启动子甲基化(ΔΔCt) |
---|---|---|
癌组织 | 17 | 5.170(4.015~5.510) |
癌旁组织 | 17 | 1.210(1.445~2.410) |
Z值 | -3.243 | |
P值 | <0.001 |
病理特征 | 例数 | ΔSorCS1基因 | ΔCASR基因 | SEPT9基因 |
---|---|---|---|---|
性别 | ||||
男性 | 9 | 0.330(0.205~0.545) | 0.280(0.075~0.440) | 31.779(4.509~109.597) |
女性 | 8 | 0.425(0.253~0.488) | 0.245(0.225~0.500) | 17.380(4.065~81.032) |
U值 | 30.500 | 33.500 | 36.000 | |
P值 | 0.606 | 0.810 | 1.000 | |
年龄 | ||||
≤60岁 | 7 | 0.290(0.150~0.480) | 0.280(0.030~0.540) | 7.890(1.376~77.708) |
>60岁 | 10 | 0.445(0.300~0.543) | 0.225(0.080~0.415) | 39.478(4.650~226.364) |
U值 | 48.500 | 33.500 | 24.000 | |
P值 | 0.193 | 0.884 | 0.283 | |
肿瘤分期 | ||||
Ⅰ~Ⅱ | 4 | 0.205(0.143~0.283) | 0.235(0.070~0.355) | 2.802(0.401~5.797) |
Ⅲ~Ⅳ | 13 | 0.480(0.325~0.520) | 0.300(0.070~0.515) | 47.177(8.508~116.131) |
U值 | 46.000 | 21.500 | 3.000 | |
P值 | 0.023 | 0.610 | 0.009 | |
淋巴结转移 | ||||
无 | 8 | 0.275(0.173~0.443) | 0.145(0.008~0.475) | 6.340(2.436~41.102) |
有 | 9 | 0.490(0.360~0.545) | 0.380(0.120~0.440) | 82.139(25.634~455.087) |
U值 | 56.500 | 25.000 | 21.000 | |
P值 | 0.046 | 0.290 | 0.015 | |
病理特征 | 例数 | ΔSorCS1基因 | ΔCASR基因 | EPT9基因 |
肿瘤部位 | ||||
直肠 | 10 | 0.400(0.218~0.513) | 0.285(0.075~0.550) | 8.508(2.612~41.791) |
结肠 | 7 | 0.400(0.260~0.500) | 0.280(0.050~0.380) | 69.071(4.509~302.605) |
U值 | 33.500 | 27.500 | 10.000 | |
P值 | 0.887 | 0.464 | 0.149 | |
肿瘤直径① | ||||
≤5 cm | 12 | 0.345(0.173~0.498) | 0.290(0.045~0.528) | 8.508(3.149~75.549) |
>5 cm | 4 | 0.390(0.323~0.518) | 0.240(0.063~0.388) | 64.658(15.387~783.230) |
U值 | 30.000 | 22.500 | 14.000 | |
P值 | 0.521 | 0.856 | 0.225 |
病理特征 | 例数 | ΔSorCS1基因 | ΔCASR基因 | SEPT9基因 |
---|---|---|---|---|
性别 | ||||
男性 | 9 | 0.330(0.205~0.545) | 0.280(0.075~0.440) | 31.779(4.509~109.597) |
女性 | 8 | 0.425(0.253~0.488) | 0.245(0.225~0.500) | 17.380(4.065~81.032) |
U值 | 30.500 | 33.500 | 36.000 | |
P值 | 0.606 | 0.810 | 1.000 | |
年龄 | ||||
≤60岁 | 7 | 0.290(0.150~0.480) | 0.280(0.030~0.540) | 7.890(1.376~77.708) |
>60岁 | 10 | 0.445(0.300~0.543) | 0.225(0.080~0.415) | 39.478(4.650~226.364) |
U值 | 48.500 | 33.500 | 24.000 | |
P值 | 0.193 | 0.884 | 0.283 | |
肿瘤分期 | ||||
Ⅰ~Ⅱ | 4 | 0.205(0.143~0.283) | 0.235(0.070~0.355) | 2.802(0.401~5.797) |
Ⅲ~Ⅳ | 13 | 0.480(0.325~0.520) | 0.300(0.070~0.515) | 47.177(8.508~116.131) |
U值 | 46.000 | 21.500 | 3.000 | |
P值 | 0.023 | 0.610 | 0.009 | |
淋巴结转移 | ||||
无 | 8 | 0.275(0.173~0.443) | 0.145(0.008~0.475) | 6.340(2.436~41.102) |
有 | 9 | 0.490(0.360~0.545) | 0.380(0.120~0.440) | 82.139(25.634~455.087) |
U值 | 56.500 | 25.000 | 21.000 | |
P值 | 0.046 | 0.290 | 0.015 | |
病理特征 | 例数 | ΔSorCS1基因 | ΔCASR基因 | EPT9基因 |
肿瘤部位 | ||||
直肠 | 10 | 0.400(0.218~0.513) | 0.285(0.075~0.550) | 8.508(2.612~41.791) |
结肠 | 7 | 0.400(0.260~0.500) | 0.280(0.050~0.380) | 69.071(4.509~302.605) |
U值 | 33.500 | 27.500 | 10.000 | |
P值 | 0.887 | 0.464 | 0.149 | |
肿瘤直径① | ||||
≤5 cm | 12 | 0.345(0.173~0.498) | 0.290(0.045~0.528) | 8.508(3.149~75.549) |
>5 cm | 4 | 0.390(0.323~0.518) | 0.240(0.063~0.388) | 64.658(15.387~783.230) |
U值 | 30.000 | 22.500 | 14.000 | |
P值 | 0.521 | 0.856 | 0.225 |
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