Abstract:

Objective To investigate the comparability of glycated hemoglobin A_1c（HbA_1c） determination using finger peripheral blood and venous blood by MQ-6000 glycated hemoglobin analyzer（MQ-6000） and the clinical application value of peripheral blood for the determination of HbA_1c. Methods A total of 97 patients with diabetes mellitus were enrolled,and 39 healthy subjects were enrolled as control group. Finger peripheral blood and venous blood were used for HbA_1c determination by MQ-6000,and the results were compared with those using venous blood determined by VARIANT Ⅱ hemoglobin testing system（VARIANT Ⅱ）. Results There was no statistical significance for the results of HbA_1c determination between using peripheral blood and venous blood in control and diabetes mellitus groups（P>0.05）,and there was a good correlation between using peripheral blood and venous blood（r=0.996）. MQ-6000 had a good correlation with VARIANT Ⅱ（r=0.992）. Conclusions Finger peripheral blood can replace venous blood for the determination of HbA_1c and be used for the screening,diagnosis and monitoring of diabetes mellitus.

Key words: Glycated hemoglobin A_1c, Peripheral blood, Venous blood, Diabetes mellitus