Abstract:

Objective To investigate the changes of coagulation function in early stage among rib fracture patients with mild to moderate injury severity score （ISS）. Methods The changes of coagulation function in early stage among 95 rib fracture patients with mild to moderate ISS were analyzed retrospectively. The coagulation function was determined by coagulation-colorimetry method. The clinical data were collected. Results The medians（M）of abbreviated injury scale （AIS） and ISS were 3 （1-4）and 11 （2-41）,respectively. The levels of fibrinogen degradation product,fibrinogen,thrombin time and D-dimer were 6.80（4.10-17.30）mg/L,（4.23±0.45）g/L,（19.45±1.30）s and 1 560.00（757.00-4 732.00）μg/L,which were higher than their reference values（P<0.05）. The levels of antithrombin Ⅲ,international normalized ratio and activated partial thromboplastin time （APTT） were （87.30 ±14.15）%,0.97±0.08 and （29.12±4.28） s,which were lower than their reference values（P<0.05）. The levels of prothrombin and prothrombin time （PT） activity were （11.17±0.89）s and （107.91±16.76）%,with no statistical significance compared with their reference values （P>0.05）. Correlation analysis showed that ISS was rank correlated with fibrinogen degradation product and D-dimer （rs=0.283 and 0.308）（P<0.05）. AIS was rank correlated with fibrinogen degradation product and D-dimer （rs=0.224 and 0.226）（P<0.05）. Conclusions The coagulation function in early stage among rib fracture patients with mild to moderate ISS is changed obviously,mainly in high-level fibrinolytic function and coagulation state,and high-level fibrinolytic function is related to the severity of trauma.

Key words: Coagulation function, Rib fracture, Mild to moderate injury, Early stage of trauma