Role of CD73 in cancer

doi:10.3969/j.issn.1673-8640.2017.07.023

Abstract

Abstract:

Purine plays an important role in cancer progression,and is regulated by a series of nucleotidases. CD73 is one of key enzymes. CD73 can catalyze adenosine monophosphate（AMP）breakdown to adenosine,and is found to be overexpressed in many types of cancers. There are various factors and mechanisms for regulating the expression of CD73. More and more studies have shown that CD73 is a key regulatory molecule of in vitro cancer cell proliferation,migration and invasion and in vivo tumor angiogenesis and tumor immune escape. Evidences in in vivo model prove that targeted blockade of CD73 could be a favorable therapeutic approach for cancer patients. This review will summarize the roles of CD73 in cancer development,including tumor angiogenesis,tumor growth and metastasis,suppressing the efficiency of immune response and the status of anti-CD73 cancer therapy.

Key words: CD73, Adenosine, Targeted therapy, Caneer

CLC Number:

R446.62

GAO Yaoyi, MA Xiaolu, WU Jiong, GUO Wei, PAN Baishen. Role of CD73 in cancer[J]. Laboratory Medicine, 2017, 32(7): 656-662.

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