Relationship of maternal sex hormones,IGF-1 and 25（OH）D in serum during pregnancy

doi:10.3969/j.issn.1673-8640.2017.011.007

Abstract

Abstract:

Objective To investigate the relationship of maternal sex hormones,insulin-like growth factor-1（IGF-1） and 25-hydroxyvitamin D [25（OH）D] in serum during pregnancy. Methods By random method,362 pregnant women in the first trimester of pregnancy were enrolled as experimental group,and 136 non-pregnant women were enrolled as control group with similar age and blood extraction time. All participants were subclassified according to season of blood extraction. The first group was from January to June（125 cases of experimental groupⅠ and 62 cases of control groupⅠ）,and the second group was from July to December（237 cases of experimental groupⅡ and 74 cases of control groupⅡ）. Correlation and linear regression models were used to assess the relations of maternal sex hormones,IGF-1 and 25（OH）D. Results Serum 25（OH）D levels in different months had difference,the lowest level was in April [（24.1±7.9）nmol/ L],and the highest level was in August [（50.2±8.3）nmol/L]. There was statistical significance between experimental groupⅠand experimental group Ⅱ（P=0.006）. Serum 25（OH）D level in multiparous women [（39.7±8.4）nmol/L] was higher than that in primiparous women [（30.8±7.9）nmol/L,P=0.013]. Serum 25（OH）D,estradiol,progesterone and 17-hydroxyprogesterone（17-OHP） levels were higher in experimental group than those in control group. There was no statistical significance for testosterone,rostenedione and IGF-1 between experimental and control groups（P>0.05）. Serum 25（OH）D levels and multiparous times had weakly positive correlation（r=0.21,P=0.04）. Serum 25（OH）D levels and maternal sex hormones,IGF-1 had weak correlation. When serum 25（OH）D levels increased by 1 IU,the levels of estradiol decreased by 7.9%. For different levels of 25（OH）D,maternal sex hormones and IGF-1 of pregnant women had no statistical significance（P>0.05）. Conclusions There is no correlation between maternal sex hormones and IGF-1 during the first trimester of pregnancy.

Key words: 25-Hydroxyvitamin D, Estradiol, Sex hormone, Insulin-like growth factor-1, The first trimester of pregnancy

CLC Number:

R446.62

WANG Juan, LI Yindi. Relationship of maternal sex hormones,IGF-1 and 25（OH）D in serum during pregnancy[J]. Laboratory Medicine, 2017, 32(11): 970-974.

Figures/Tables 2

References 16

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组别	年龄（岁）	25（OH）D（nmol/L）	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP（ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
第1组
实验组Ⅰ	31.8±4.0	34.8±8.6	6.32±2.80	35.90±5.30	2.57±1.00	1.29±0.70	3.69±0.70	172.3±12.9
对照组Ⅰ	30.2±4.9	31.6±7.2	0.22±0.10	16.90±7.20	1.02±0.80	1.38±0.50	2.62±0.90	183.4±13.4
P值	0.735	0.032	<0.001	<0.001	0.038	0.582	0.136	0.358
第2组
实验组Ⅱ	30.6±2.7	39.4±9.2	6.28±3.20	34.90±6.80	2.56±0.90	1.28±0.50	3.72±0.80	169.8±13.4
对照组Ⅱ	31.1±3.2	34.6±8.3	0.23±0.20	17.60±7.60	0.96±0.60	1.36±0.70	2.49±1.20	159.4±16.9
P值	0.681	0.045	<0.001	<0.001	0.047	0.657	0.145	0.426

组别	年龄（岁）	25（OH）D（nmol/L）	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP（ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
第1组
实验组Ⅰ	31.8±4.0	34.8±8.6	6.32±2.80	35.90±5.30	2.57±1.00	1.29±0.70	3.69±0.70	172.3±12.9
对照组Ⅰ	30.2±4.9	31.6±7.2	0.22±0.10	16.90±7.20	1.02±0.80	1.38±0.50	2.62±0.90	183.4±13.4
P值	0.735	0.032	<0.001	<0.001	0.038	0.582	0.136	0.358
第2组
实验组Ⅱ	30.6±2.7	39.4±9.2	6.28±3.20	34.90±6.80	2.56±0.90	1.28±0.50	3.72±0.80	169.8±13.4
对照组Ⅱ	31.1±3.2	34.6±8.3	0.23±0.20	17.60±7.60	0.96±0.60	1.36±0.70	2.49±1.20	159.4±16.9
P值	0.681	0.045	<0.001	<0.001	0.047	0.657	0.145	0.426

组别	例数	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP （ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
25（OH）D低水平组	164	6.35±2.34	35.70±5.69	2.77±1.04	1.24±0.71	3.67±0.67	172.5±11.6
25（OH）D高水平组	198	6.27±2.17	36.20±4.95	2.45±0.96	1.38±0.64	3.73±0.72	183.6±13.5
P值		0.37	0.74	0.63	0.26	0.95	0.35

组别	例数	雌二醇（ng/mL）	孕酮（ng/mL）	17-OHP （ng/mL）	睾酮（ng/mL）	雄烯二酮（ng/mL）	IGF-1 （μg/mL）
25（OH）D低水平组	164	6.35±2.34	35.70±5.69	2.77±1.04	1.24±0.71	3.67±0.67	172.5±11.6
25（OH）D高水平组	198	6.27±2.17	36.20±4.95	2.45±0.96	1.38±0.64	3.73±0.72	183.6±13.5
P值		0.37	0.74	0.63	0.26	0.95	0.35