Research on the current situation of dendritic cell related receptors' role in Aspergillus fumigatus infection

doi:10.3969/j.issn.1673-8640.2016.01.015

Abstract

Abstract:

Aspergillus fumigatus is a kind of opportunistic pathogens,and once the infection occurs in patients with immunosuppression,the fatality rate is as high as 60%-80%. As a kind of full-time antigen presented cells,dendritic cells（DC） connect inherent immunity and adaptive immunity. They can recognize different spores and hyphae of Aspergillus fumigatus by their receptors,and secrete corresponding inflammatory factor after consuming pathogenic bacteria to adjust the maturation and differentiation of Th cells and thereby effectively resist Aspergillus fumigatus infection at last. So DC receptors may play a key role in this process,and this review focuses on the DC related receptors' role in Aspergillus fumigatus infection.

Key words: Dendritic cell, Receptor, Aspergillus fumigatus

CLC Number:

R446.62

MA Ning, CHEN Xianfeng, YANG Min, FU Haitao, QIN Baodong, ZHONG Renqian. Research on the current situation of dendritic cell related receptors' role in Aspergillus fumigatus infection[J]. Laboratory Medicine, 2016, 31(1): 66-70.

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