Study on the coagulation function in late-pregnancy women with viral hepatitis and its clinical significance

doi:10.3969/j.issn.1673-8640.2015.03.011

Abstract

Abstract: Objective

To observe the variation of coagulation function and discuss its clinical significance in late-pregnancy women with viral hepatitis.

Methods

A total of 134 late-pregnancy women with viral hepatitis were classified into 5 subgroups: acute hepatitis(39 cases), chronic mild hepatitis(43 cases), chronic moderate/severe hepatitis(25 cases), cirrhosis(15 cases) and severe hepatitis(12 cases) groups. The prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (FIB) were determined and compared with the results of 45 normal late pregnant women. Meanwhile, the blood coagulation factors, including FⅡ, FⅤ, FⅦ, FⅧ, FⅨ, FⅪ and FⅫ, of 23 chronic mild hepatitis patients, 13 chronic moderate hepatitis patients, 10 cirrhosis patients and 26 normal late pregnant women, were measured respectively.

Results

Compared with normal late pregnancy group, PT and APTT were prolonged in severe hepatitis group (P<0.05). FIB decreased in both cirrhosis group and severe hepatitis group (P<0.05, P<0.01). FⅦ:C in chronic mild hepatitis and chronic moderate hepatitis groups were lower than that in normal pregnant group. Most coagulation factors, except FⅧ:C, in cirrhosis group were lower than those in the normal late-pregnancy group (P<0.05).

Conclusions

Coagulation function in late-pregnancy women is affected with viral hepatitis. It is of great clinical significance to determine the coagulation indices for preventing postnatal hemorrhea and other complications.

Key words: Coagulation, Late pregnancy, Viral hepatitis

CLC Number:

R446.1

FU Jie, ZHANG Rui, XIE Lili, LI Jianwei, DONG Zhiwu. Study on the coagulation function in late-pregnancy women with viral hepatitis and its clinical significance[J]. Laboratory Medicine, 2015, 30(3): 247-249.

Figures/Tables 2

References 12

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组别	例数	PT(s)	APTT(s)	FIB(g/L)
正常组	45	10.49±0.64	28.69±3.09	4.07±0.47
急性肝炎组	39	11.25±1.16	28.20±4.04	4.01±0.82
慢性肝炎轻度组	43	10.94±0.81	27.87±3.21	3.72±0.67
慢性肝炎中重度组	25	11.40±1.45	28.06±3.73	3.20±0.54
肝硬化组	15	15.02±1.84	29.54±3.36	2.15±1.32^*
重症肝炎组	12	28.13±5.87^*	50.28±7.42^*	0.91±0.79^**

组别	例数	PT(s)	APTT(s)	FIB(g/L)
正常组	45	10.49±0.64	28.69±3.09	4.07±0.47
急性肝炎组	39	11.25±1.16	28.20±4.04	4.01±0.82
慢性肝炎轻度组	43	10.94±0.81	27.87±3.21	3.72±0.67
慢性肝炎中重度组	25	11.40±1.45	28.06±3.73	3.20±0.54
肝硬化组	15	15.02±1.84	29.54±3.36	2.15±1.32^*
重症肝炎组	12	28.13±5.87^*	50.28±7.42^*	0.91±0.79^**

组别	例数	FⅡ:C	FⅤ:C	FⅦ:C	FⅧ:C	FⅨ:C	FⅪ:C	FⅫ:C
正常晚孕组	26	177.8±40.6	175.8±35.7	283.5±56.7	243.4±96.1	141.8±47.2	73.4±9.7	121.3±25.4
慢性肝炎轻度组	23	162.9±28.1	165.7±40.8	213.1±68.5^*	239.5±74.3	147.3±34.8	70.7±16.9	107.4±27.3
慢性肝炎中重度组	13	86.7±57.3	85.9±68.4	159.7±81.5^*	228.8±67.5	105.3±49.6	65.5±27.2	78.2±38.6
肝硬化组	10	74.3±51.5^*	65.7±35.4^*	79.5±40.2^*	294.2±82.4^*	77.3±32.9^*	58.5±15.4^*	66.8±41.1^*

组别	例数	FⅡ:C	FⅤ:C	FⅦ:C	FⅧ:C	FⅨ:C	FⅪ:C	FⅫ:C
正常晚孕组	26	177.8±40.6	175.8±35.7	283.5±56.7	243.4±96.1	141.8±47.2	73.4±9.7	121.3±25.4
慢性肝炎轻度组	23	162.9±28.1	165.7±40.8	213.1±68.5^*	239.5±74.3	147.3±34.8	70.7±16.9	107.4±27.3
慢性肝炎中重度组	13	86.7±57.3	85.9±68.4	159.7±81.5^*	228.8±67.5	105.3±49.6	65.5±27.2	78.2±38.6
肝硬化组	10	74.3±51.5^*	65.7±35.4^*	79.5±40.2^*	294.2±82.4^*	77.3±32.9^*	58.5±15.4^*	66.8±41.1^*

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