Abstract:

Objective　 To analyze the resistant characterization,phylogenetic grouping and genetic relatedness of Escherichia coli in urinary tract infection, and compare the differences of these factors among the hospital and community infections. Methods　 A total of 185 non-duplicate Escherichia coli in urinary tract infection were analyzed for sensitivities, extended spectrum beta-lactamases (ESBLs) screening, phylogenetic grouping and genetic relatedness, and the results were analyzed statistically. Results　 The resistance rates to multiple antibiotics were>49.0%. A total of 185 isolates displayed a high diversity, and the prevalence of ESBLs was 78.4%. Phylogroup D Escherichia coli was the most frequent(49.7%), and the correlation between the production rate of ESBLs and resistance to cefotaxime was observed (P<0.05). Additionally, there was no statistical significant on the distribution of the factors between the hospital and community infections (P>0.05). Conclusions　 Urinary tract infection is mainly caused by the phylogroup D Escherichia coli which displays a high diversity of genetic relatedness. High-produced ESBLs are multiple resistant to antibiotics.

Key words: Escherichia coli, Urinary tract infection, Phylogenetic grouping, Genetic relatedness