Significance of plasma 1，3-beta-D-glucan assay for the diagnosis of invasive fungal diseases in patients with malignant hematological diseases

doi:10.3969/j.issn.1673-8640.2013.01.002

Abstract

Abstract: Objective　To evaluate the significance of plasma 1，3-beta-D-glucan assay(G test)for the diagnosis of invasive fungal diseases（IFD）in patients with malignant hematological diseases. Methods　A retrospective analysis was performed in 220 inpatients with malignant hematological trmor．According to Diagnostic Criteria and Principles of Treatment of Invasive Fungal Infections in Patients with Blood Diseases/Malignancies as gold standard，the plasma 1，3-beta-D-glucan concentration′s area under the receiver operating characteristic（ROC）curve，sensitivity，specificity and time to diagnosis in the diagnosis of IFD were analyzed. Results　Comparing the gold standard，the plasma 1，3-beta-D-glucan concentration′s area under the ROC curve，sensitivity，specificity and time to diagnosis were 0.946 1，98.6%，83.0% and（3.86±2.92)d，respectively. Conclusions　G test has good sensitivity and time to diagnosis for the diagnosis of IFD in patients with malignant hematological diseases，and has a good negative predictive value in early diagnosis and exclusion of IFD. It can improve the efficiency and reduce the care burden of patient.

Key words: 1, 3-beta-D-glucan, Malignant hematological disease, Invasive fungal disease

CHEN Yan 1，WANG Shuhui 2，HUANG Baoqing 2，NI Xiong 3，HUANG Xiaochun 1，QIN Yanghua 1. Significance of plasma 1，3-beta-D-glucan assay for the diagnosis of invasive fungal diseases in patients with malignant hematological diseases[J]. , 2013, 28(1): 7-10.

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