血小板颗粒释放机制及其对标本检验前变异影响研究进展

doi:10.3969/j.issn.1673-8640.2021.05.020

检验医学 ›› 2021, Vol. 36 ›› Issue (5): 560-564.DOI: 10.3969/j.issn.1673-8640.2021.05.020

血小板颗粒释放机制及其对标本检验前变异影响研究进展

张式鸿¹, 房邦仁², 叶曼曼¹, 邓冠华²

1.中山大学附属第一医院检验科,广东广州 510080
2.广州阳普医疗科技股份有限公司广东省医用材料血液相容性研究企业重点实验室,广东广州 510530

收稿日期:2019-12-13 出版日期:2021-05-30 发布日期:2021-05-30
通讯作者: 邓冠华
作者简介:邓冠华,联系电话:020-32218168。
张式鸿,男,1968年生,学士,副主任技师,主要从事临床血液学研究;
房邦仁,男,1990年生,硕士,主要从事采血管表面血小板行为的研究。第一联系人：张式鸿与房邦仁对本研究具有同等贡献,并列为第一作者。

Research progress on the mechanism of platelet granule release and its effect on specimen preanalytical variation

ZHANG Shihong¹, FANG Bangren², YE Manman¹, DENG Guanhua²

1. Department of Clinical Laboratory,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong,China
2. Guangzhou Improve Medical Technology Co.,Ltd.,Enterprise Key Laboratory for Blood Compatibility of Medical Materials,Guangzhou 510530,Guangdong,China

Received:2019-12-13 Online:2021-05-30 Published:2021-05-30
Contact: DENG Guanhua

摘要/Abstract

摘要：

血小板释放是指活化的血小板以分泌的形式释放其颗粒（α颗粒、致密颗粒和溶酶体颗粒）及内容物进入血浆的过程。近20年来,抗血小板药物的开发推动了血小板释放机制及其对临床标本检验前变异影响的研究。在体外,血小板释放与标本检验前变异紧密相关,因储血容器的材质及内部添加剂、剪切力、保存温度等因素可导致血小板形态改变、活化、功能障碍,从而影响其释放颗粒及内容物并导致标本检验前变异,最终影响检验结果。因此,有必要了解血小板释放对标本检验前变异的影响,提高检验结果的准确性。

关键词: 血小板释放, 血小板颗粒, 检验前变异

Abstract:

Platelet release refers to the process in which activates platelets release their granules（α granules,compact granules and lysosomal granules） and contents into plasma. Over the past 2 decades,the development of antiplatelet drug has led to advances in the study of platelet release mechanisms and their effects on preanalytical variation of clinical specimens. In vitro,platelet release is closely related to preanalytical variation of the specimen. Factors including the material of the blood storage vessel,internal additives,shear stress and storage temperature may induce platelet morphological changes,activation and dysfunction and consequently affect the release of platelet granules and contents. It will lead to preanalytical variation of specimens,and finally influence the results. Therefore,it is necessary to understand the effect of platelet release on preanalytical variation of specimens to improve the accuracy of results.

Key words: Platelet release, Platelet granule, Preanalytical variation

中图分类号:

R446.1

张式鸿, 房邦仁, 叶曼曼, 邓冠华. 血小板颗粒释放机制及其对标本检验前变异影响研究进展[J]. 检验医学, 2021, 36(5): 560-564.

ZHANG Shihong, FANG Bangren, YE Manman, DENG Guanhua. Research progress on the mechanism of platelet granule release and its effect on specimen preanalytical variation[J]. Laboratory Medicine, 2021, 36(5): 560-564.

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血小板颗粒释放机制及其对标本检验前变异影响研究进展

Research progress on the mechanism of platelet granule release and its effect on specimen preanalytical variation

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