NLR和PLR与高脂血症的相关性分析

doi:10.3969/j.issn.1673-8640.2020.08.006

摘要/Abstract

摘要：

目的探讨中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）与高脂血症（HLP）的相关性。方法回顾性分析495例HLP患者（HLP组）和500名健康体检者（对照组）的实验室检测结果。结果 HLP组NLR和PLR明显高于对照组（P=0.007）。单因素分析结果显示,白细胞、血红蛋白水平、NLR、PLR与HLP呈中度相关。受试者工作特征（ROC）曲线分析发现,NLR的最佳临界值为1.71（P<0.001）,敏感性为68.0%,特异性为78.5%,NLR的预测强度优于其他指标,且HLP的严重程度与NLR呈高度正相关。结论 HLP患者的NLR和PLR明显高于健康体检者,NLR随HLP严重程度相应上升。

关键词: 高脂血症, 心脑血管疾病, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值

Abstract:

Objective To investigate the correlations of neutrophil-to-lymphocyte ratio（NLR） and platelet-to-lymphocyte ratio（PLR） with hyperlipidemia（HLP）. Methods The study included 495 patients with HLP,and their results of laboratory parameters were analyzed retrospectively. Totally,500 healthy subjects were enrolled as control group. Results HLP group had higher NLR and PLR compared to those of control group（P=0.007）. In the univariate analysis,white blood cell,hemoglobin,NLR and PLR were moderately correlated with HLP. Receiver operating characteristic（ROC） curve analysis showed that the optimal cut-off value for NLR was 1.71（P<0.001）. The sensitivity was 68.0%,and the specificity was 78.5%. The predictive strength of NLR was better than those of the other parameters. A strong positive correlation was revealed between the severity of HLP and NLR. Conclusions Patients with HLP have higher NLR and PLR compared to healthy subjects. NLR increases with the severity of HLP.

Key words: Hyperlipidemia, Cardiovascular and cerebrovascular disease, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio

中图分类号:

R446.1

张弢, 刘琴, 刘爱平, 丁耀东. NLR和PLR与高脂血症的相关性分析[J]. 检验医学, 2020, 35(8): 767-770.

ZHANG Tao, LIU Qin, LIU Aiping, DING Yaodong. Correlations of NLR and PLR with hyperlipidemia[J]. Laboratory Medicine, 2020, 35(8): 767-770.

图/表 5

参考文献 12

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项目	回归系数	95%CI	OR值	P值
ALT	-0.033	0.955~0.976	0.958	<0.001
AST	-0.049	0.931~974	0.952	<0.001
TB	-0.058	1.020~1.100	1.059	0.19
Alb	-0.080	0.878~0.972	0.996	0.011
Glu	0.356	0.509~0.963	0.701	0.029
HbA_1c	-0.874	0.260~0.669	0.417	0.003
FT₄	-0.100	0.849~0.964	0.905	<0.001
FT₃	-0.269	0.589~0.992	0.764	0.043
Hb	-0.032	0.958~0.980	0.969	<0.001
RDW	-0.004	1.007~1.100	1.052	0.025
WBC计数	0.010	0.874~1.302	1.010	0.044
NEUT#	-0.154	0.746~0.985	0.857	0.029
PLT计数	-0.004	0.993~0.998	0.996	<0.001
NLR	0.32	1.103~1.758	1.405	0.016
PLR	0.105	1.022~1.657	1.291	0.023

项目	回归系数	95%CI	OR值	P值
ALT	-0.033	0.955~0.976	0.958	<0.001
AST	-0.049	0.931~974	0.952	<0.001
TB	-0.058	1.020~1.100	1.059	0.19
Alb	-0.080	0.878~0.972	0.996	0.011
Glu	0.356	0.509~0.963	0.701	0.029
HbA_1c	-0.874	0.260~0.669	0.417	0.003
FT₄	-0.100	0.849~0.964	0.905	<0.001
FT₃	-0.269	0.589~0.992	0.764	0.043
Hb	-0.032	0.958~0.980	0.969	<0.001
RDW	-0.004	1.007~1.100	1.052	0.025
WBC计数	0.010	0.874~1.302	1.010	0.044
NEUT#	-0.154	0.746~0.985	0.857	0.029
PLT计数	-0.004	0.993~0.998	0.996	<0.001
NLR	0.32	1.103~1.758	1.405	0.016
PLR	0.105	1.022~1.657	1.291	0.023

项目	AUC	95%CI	最佳临界值	敏感性	特异性	P 值
WBC计数	0.551	0.515~0.587	6.03	0.564	0.606	0.005
Hb	0.538	0.502~0.574	154.50	0.533	0.654	0.038
NLR	0.652	0.596~0.681	1.71	0.680	0.785	<0.001
PLR	0.628	0.583~0.663	106.43	0.618	0.640	<0.001

项目	AUC	95%CI	最佳临界值	敏感性	特异性	P 值
WBC计数	0.551	0.515~0.587	6.03	0.564	0.606	0.005
Hb	0.538	0.502~0.574	154.50	0.533	0.654	0.038
NLR	0.652	0.596~0.681	1.71	0.680	0.785	<0.001
PLR	0.628	0.583~0.663	106.43	0.618	0.640	<0.001

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