关键词: 凝血因子ⅩⅢ, 白细胞介素6, 肿瘤坏死因子α, 脑卒中

Abstract:

Objective To investigate the changes of coagulation factorⅩⅢ（FⅩⅢ） and cytokines in stroke patients. Methods A total of 47 hemorrhagic stroke patients and 183 ischemic stroke patients were enrolled,and 50 healthy subjects were enrolled as healthy control group. The levels of FⅩⅢ,D-dimer,antithrombin （AT） and plasminogen （PLG） were determined,and the correlations of these coagulation system indices with stroke were analyzed. The levels of interleukin 6（IL-6）,interleukin 10 （IL-10） and tumor necrosis factor alpha （TNF-α） were determined,and the correlation of cytokines with stroke was analyzed. Results The levels of FⅩⅢand PLG in patients with hemorrhagic stroke and ischemic stroke were lower than those in healthy control group（P<0.05）,the levels of D-dimer were higher than that in healthy control group（P<0.05）,and there was no statistical significance for the levels of AT between hemorrhagic stroke and ischemic stroke patients and healthy control group （P>0.05）. The level of D-dimer in patients with hemorrhagic stroke was higher than that in patients with ischemic stroke （P<0.05）. There was no statistical significance for the levels of FⅩⅢ,PLG and AT （P>0.05）. The levels of IL-6,IL-10 and TNF-α in patients with hemorrhagic stroke and ischemic stroke were higher than those in healthy control group （P<0.05）. The level of IL-6 in patients with hemorrhagic stroke was higher than that in patients with ischemic stroke（P<0.05）. There was no statistical significance for the levels of IL-10 and TNF-α （P>0.05）. Conclusions The levels of FⅩⅢ,PLG,D-dimer,IL-6,IL-10 and TNF-α play roles for the diagnosis of stroke,especially for the early diagnosis of stroke,early targeted treatment and reducing stroke morbidity and mortality.

Key words: Coagulation factorⅩⅢ, Interleukin 6, Tumor necrosis factor alpha, Stroke