急性脑梗死患者血清同型半胱氨酸水平与幽门螺杆菌感染的相关性研究

doi:10.3969/j.issn.1673-8640.2015.04.011

摘要/Abstract

摘要：

目的探讨急性脑梗死(ACI)患者血清同型半胱氨酸(Hcy)水平与幽门螺杆菌(Hp)感染的相关性。方法以120例ACI患者和70名健康体检者为研究对象,检测血清Hcy(循环酶法)、高敏C反应蛋白(hs-CRP)及血脂水平,进行Hp IgG抗体(胶体金法)检测、快速尿素酶试验(RUT)和¹⁴C尿素呼气试验(¹⁴C-UBT)。结果ACI组患者Hp感染率(71.7%)显著高于对照组(44.3%, χ²=14.009,P<0.05)。Hp感染组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、Hcy和hs-CRP水平[(6.28±0.93) mmol/L、(3.09±0.86) mmol/L、(3.83±0.97) mmol/L、(28.8±6.4) μmol/L及(7.97±2.13) mg/L]均显著高于Hp非感染组[(5.19±0.85) mmol/L、(2.27±0.74) mmol/L、(2.78±0.92) mmol/L、(19.7±5.4) μmol/L及(3.45±1.07) mg/L, t=5.601、3.235、4.336、4.261、3.318,P均<0.05],血清高密度脂蛋白胆固醇(HDL-C)水平[(1.07±0.34) mmol/L]显著低于Hp非感染组[(1.82±0.41) mmol/L, t=3.725,P<0.05]。ACI患者血清Hcy水平与Hp感染具有显著相关性(r=0.321,P<0.05)。结论ACI患者血清Hcy水平与Hp感染相关,血清Hcy水平及Hp感染结果可提示病情。

关键词: 同型半胱氨酸, 幽门螺杆菌, 相关性, 急性脑梗死

Abstract:

Objective To investigate the correlation of serum homocysteine(Hcy) and Helicobacter pylori (Hp) infection with acute cerebral infarction (ACI) patients. Methods Serum Hcy (enzymatic cycling method), high-sensitivity C reactive protein (hs-CRP) and blood lipid levels of 120 ACI patients and 70 healthy subjects were detected. Serum Hp IgG antibody (colloidal gold), rapid urease test (RUT) and ¹⁴C urea breath test (¹⁴C-UBT) were also detected and performed. Results The Hp infection rate of ACI group (71.7%) was significantly higher than that of control group (44.3%, χ²= 14.009, P<0.05).Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), Hcy and hs-CRP levels [(6.28±0.93) mmol/L, (3.09±0.86) mmol/L, (3.83±0.97) mmol/L,(28.8±6.4) μmol/L and (7.97±2.13) mg/L] in Hp infection group were significantly higher than those in Hp non-infection group [(5.19±0.85) mmol/L,(2.27±0.74) mmol/L,(2.78±0.92) mmol/L, (19.7±5.4)μmol/L and (3.45±1.07)mg/L, t=5.601, 3.235, 4.336, 4.261 and 3.318, P<0.05]. However, serum high-density lipoprotein cholesterol (HDL-C) level [(1.07±0.34) mmol/L] was significantly lower than that in Hp non-infection group [(1.82±0.41) mmol/L, t=3.725, P<0.05]. Hcy level in ACI group was significantly correlated with Hp infection (r=0.321, P<0.05). Conclusions The Hcy levels in ACI patients are correlated with Hp infection, and the levels of serum Hcy and Hp infection results could hint the state of illness.

Key words: Homocysteine, Helicobacter pylori, Correlation, Acute cerebral infarction

中图分类号:

R446.5

韩景银, 杨文东. 急性脑梗死患者血清同型半胱氨酸水平与幽门螺杆菌感染的相关性研究[J]. 检验医学, 2015, 30(4): 341-344.

HAN Jingyin, YANG Wendong. Correlation research of serum homocysteine and Helicobacter pylori infection in patients with acute cerebral infarction[J]. Laboratory Medicine, 2015, 30(4): 341-344.

图/表 1

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