microRNA相关单核苷酸多态性与肿瘤的关系

doi:10.3969/j.issn.1673-8640.2014.05.003

摘要/Abstract

摘要：

微小RNA(miRNA)是一类高度保守的非编码小RNA, 可作用于转录及转录后调控基因的表达。miRNA参与许多生物途径, 可发挥癌基因或抑癌基因的作用。miRNA相关的单核苷酸多态性(SNP)对于肿瘤的发生、发展有一定影响, 并与肿瘤的早期诊断、预后和治疗相关。本文综述了近年来发现的miRNA相关SNP与肿瘤关系的研究, 并从miRNA基因自身多态性和miRNA靶基因的SNP两方面论述其对不同肿瘤的影响和作用。

关键词: 微小RNA, 单核苷酸多态性, 肿瘤

Abstract:

MicroRNAs (miRNAs) are well-conserved small non-coding RNAs, which play roles in transcriptional and post-transcriptional regulation of gene expression. MiRNAs participate in diverse biological pathways and may act as oncogenes or tumor suppressors. Single nucleotide polymorphism(SNP) in miRNAs might promote carcinogenesis and tumor development, which may also affect early diagnosis, prognosis and treatment. Here, we highlight the association between miRNA-related SNP and tumors and describe the miRNA polymorphisms and SNP in miRNA target gene.

Key words: MicroRNA, Single nucleotide polymorphism, Tumor

中图分类号:

梁璆荔, 李姝锦, 倪培华. microRNA相关单核苷酸多态性与肿瘤的关系[J]. 检验医学, 2014, 29(5): 435-440.

LIANG Qiuli, LI Shujin, NI Peihua.. Relationship between microRNA-related single nucleotide polymorphism and tumors[J]. , 2014, 29(5): 435-440.

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