关键词: 外周血细胞形态学分级报告, 血液肿瘤, 早期筛查

Abstract:

Objective To analyze the clinical feasibility and value of peripheral blood cell morphology grading reports in the early screening of hematological malignancies. Methods Totally，1 019 664 sets of blood routine test data from patients who visited Shandong Provincial Hospital of Shandong First Medical University（Olympic District） from July 2019 to June 2024 were collected. The first peripheral blood cell morphology grading reports of patients with hematological malignancies were screened. The cases of peripheral blood cell morphology grading reports were analyzed according to gender，age，clinical department and final clinical diagnosis. Results A total of 1 010 sets of first peripheral blood cell morphology grading reports of patients with hematological malignancies were screened. The proportions of peripheral blood cell morphology grading reports in total blood routine reports from 2019 to 2024 were 0.8‰-1.1‰，and it showed an upward trend year by year. Among the 1 010 patients with hematological malignancies，there were 542 males and 468 females，and there was no statistical significance in gender（P=0.48）. The age ranged from 4 to 89 years，with a median age of 59 years（P<0.05）. The proportions of peripheral blood cell morphology grading reports in total blood routine reports in non-hematological departments were 22.1%-30.9%. In the 1 010 first peripheral blood cell morphology grading reports，the numbers of reports of one level，two levels and three levels were 108，145 and 757，respectively. Totally，694 reports were verified by bone marrow morphology-immunity-cytogenetics-molecular（MICM） for diagnosis，and 316 reports could not give the final clinical diagnosis due to the absence of MICM results. Among the reports of one level，two levels and three levels，92，80 and 516 reports were verified by bone marrow MICM for diagnosis，respectively. Conclusions Peripheral blood cell morphology grading reports are feasible and can effectively reduce the clinical missed diagnosis rate of hematological malignancies，and have value for the early screening of hematological malignancies.

Key words: Peripheral blood cell morphology grading report, Hematological malignancy, Early screening