白癜风患者自身抗体及甲状腺激素检测的临床意义

doi:10.3969/j.issn.1673-8640.2015.09.003

检验医学 ›› 2015, Vol. 30 ›› Issue (9): 877-880.DOI: 10.3969/j.issn.1673-8640.2015.09.003

白癜风患者自身抗体及甲状腺激素检测的临床意义

吴俊琪¹, 姚爱萍², 王美燕¹, 蒋亦秀², 陆晓东¹

1. 浙江大学金华医院检验科,浙江金华 321000
2. 金华市第五医院皮肤科,浙江金华 321000

收稿日期:2014-10-24 出版日期:2015-09-30 发布日期:2015-09-29
作者简介:null
作者简介:吴俊琪,男,1968年生,学士,主任技师,主要从事临床免疫检验及管理工作。
基金资助:
金华市科技局社会发展类重点科研项目(2010-3-056)

Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo

WU Junqi¹, YAO Aiping², WANG Meiyan¹, JIANG Yixiu², LU Xiaodong¹

1. Department of Clinical Laboratory, Jinhua Hospital of Zhejiang University, Zhejiang Jinhua 321000,China
2. Department of Dermatology, Jinhua Fifth Hospital, Zhejiang Jinhua 321000, China

Received:2014-10-24 Online:2015-09-30 Published:2015-09-29

摘要/Abstract

摘要： 目的

探讨白癜风患者血清中自身抗体和甲状腺激素的水平及临床意义。

方法

分别用间接免疫荧光法、免疫印迹法、化学发光法检测123例白癜风患者和60名正常对照者抗核抗体(ANA)、抗核抗体谱(ANAS)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TG-Ab)和甲状腺过氧化物酶抗体(TPO-Ab), 并对白癜风组和正常对照组间的以上检测指标进行比较分析。

结果

白癜风组ANA、TG-Ab、TPO-Ab阳性率高于正常对照组(P均<0.01), ANAS阳性率2个组间比较差异无统计学意义(P>0.05);FT3、FT4水平2个组间比较差异无统计学意义(P均>0.05),TSH水平白癜风组高于正常对照组(P<0.05)。

结论

白癜风与甲状腺自身免疫性疾病之间关系密切, ANA、TG-Ab、TPO-Ab及TSH可作为白癜风患者伴有自身免疫性疾病的常用检测指标。

关键词: 自身抗体, 甲状腺激素, 自身免疫, 白癜风

Abstract: Objective

To investigate the levels and clinical significance of serum autoantibodies and thyroid hormone in patients with vitiligo.

Methods

The anti-nuclear antibody (ANA), anti-nuclear antibody spectrum(ANAS), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) were determined in 123 patients with vitiligo and 60 healthy controls by indirect immunofluorescence, immunoblotting and chemiluminescence. The determination items were statistically compared between vitiligo group and control group.

Results

The positive rates of ANA, TG-Ab and TPO-Ab in vitiligo group were higher than those in control group(P<0.01), while ANAS was not statistically significant between the 2 groups (P>0.05). FT3 and FT4 were not statistically significant in the 2 groups(P>0.05). TSH in vitiligo group was higher than that in control group (P<0.05).

Conclusions

The relationship is close between vitiligo and thyroid autoimmune diseases. ANA, TG-Ab, TPO-Ab and TSH determinations can be usually used in vitiligo patients with autoimmune diseases.

Key words: Autoantibody, Thyroid hormone, Autoimmune, Vitiligo

中图分类号:

R446.62

吴俊琪, 姚爱萍, 王美燕, 蒋亦秀, 陆晓东. 白癜风患者自身抗体及甲状腺激素检测的临床意义[J]. 检验医学, 2015, 30(9): 877-880.

WU Junqi, YAO Aiping, WANG Meiyan, JIANG Yixiu, LU Xiaodong. Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo[J]. Laboratory Medicine, 2015, 30(9): 877-880.

图/表 2

参考文献 16

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组别	例数	ANA阳性	ANAS阳性	TG-Ab阳性	TPO-Ab阳性
白癜风组	123	28(22.76)^**	8(6.50)	20(16.26)^*	21(17.15)^*
正常对照组	60	2(3.33)	1(1.66)	3(5.00)	2(3.33)

组别	例数	ANA阳性	ANAS阳性	TG-Ab阳性	TPO-Ab阳性
白癜风组	123	28(22.76)^**	8(6.50)	20(16.26)^*	21(17.15)^*
正常对照组	60	2(3.33)	1(1.66)	3(5.00)	2(3.33)

组别	例数	FT3(pmol/L)	FT4 (pmol/L)	TSH (mIU/L)
白癜风组	123	4.52±1.52	15.23±3.66	2.77±1.02^*
正常对照组	60	4.63±1.66	14.36±3.92	2.13±0.96

组别	例数	FT3(pmol/L)	FT4 (pmol/L)	TSH (mIU/L)
白癜风组	123	4.52±1.52	15.23±3.66	2.77±1.02^*
正常对照组	60	4.63±1.66	14.36±3.92	2.13±0.96

白癜风患者自身抗体及甲状腺激素检测的临床意义

Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo

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