关键词: 巨细胞病毒, 特发性血小板减少性紫癜, 临床特征, 巨核细胞, 疗效

Abstract: Objective　To study the relationship between the idiopathic thrombocytopenic purpura（ITP）and the infection of cytomegalovirus（CMV）, the clinical symptom of ITP，and the curative effect of ITP patients with CMV infection.   Methods　The 153 cases of ITP in-patients in hospital were studied. All patients were measured the antigens of CMV PP65 of white blood cell in peripheral blood. The general data, clinical manifestation, laboratory examination and treatments of 3 investigated groups were analyzed by cytomorphology and statistics methods. Results　The infective rate of CMV in ITP patients was 20.3%.The average age of ITP patients with CMV infection was 20.03±11.7. The ITP patients with CMV infection were inclined to suffer from skin hemorrhage. In the ITP patients with CMV infection, the average of marrow megacaryocyte numbers was lower than that of the negative controls，and megakaryocytic maturation lag was earlier. The general effective ratio in ITP patients with CMV infection treated with glucocorticoids was 35.5%. The total effective ratio of combined therapy，as glucocorticoids and ganciclovir (GCV), in ITP patients with CMV infection was 85.0%. Conclusions　CMV may be one of the viruses causing ITP disease. The ITP patients with CMV infection are inclined to occur skin hemorrhage. The marrow megacaryocyte productive reaction of ITP patients with CMV infection was inferior to that of negative controls，and megakaryocytic maturation lag is earlier. The curative effect of glucocorticoids is low. The combined therapy of glucocorticoids and GCV could improve curative effect.

Key words: Cytomegalovirus, Idiopathic thrombocytopenic purpura, Clinical characteristic, Megacaryocyte, Curative effect