血清AMH、FSH、InhB与精子参数的相关性分析

doi:10.3969/j.issn.1673-8640.2021.010.012

检验医学 ›› 2021, Vol. 36 ›› Issue (10): 1047-1049.DOI: 10.3969/j.issn.1673-8640.2021.010.012

血清AMH、FSH、InhB与精子参数的相关性分析

刘秀菊, 李高驰, 阳红梅, 林建春

深圳市龙岗区妇幼保健院,广东深圳 518100

收稿日期:2020-07-26 出版日期:2021-10-30 发布日期:2021-11-08
作者简介:刘秀菊,女,1982年生,硕士,副主任技师,主要从事临床检验工作。
基金资助:
深圳市科技计划项目(JCYJ20180305125647151);深圳市龙岗区卫生科技项目(20160607165514904)

Relationship between serum AMH,FSH,InhB and sperm parameters

LIU Xiuju, LI Gaochi, YANG Hongmei, LIN Jianchun

Maternal and Child Health Care Hospital of Longgang District,Shenzhen 518100,Guangdong,China

Received:2020-07-26 Online:2021-10-30 Published:2021-11-08

摘要/Abstract

摘要： 目的探讨血清抗米勒管激素（AMH）、卵泡刺激素（FSH）、抑制素B（InhB）与精子参数的关系,及其在男性不育症诊断中的价值。方法根据精子参数和睾丸活检结果将97例患者分为梗阻性无精子症组（15例）、非梗阻性无精子症组（12例）、少弱精子症组（70例）,以122名精液质量合格的男性为对照组。分析精子总数、精子浓度、精子活力、前向运动精子百分率和血清AMH、FSH、InhB的相关性。结果与对照组和梗阻性无精子症组比较,非梗阻性无精子症组、少弱精子症组血清AMH、FSH、InhB水平差异有统计学意义（P<0.05）。AMH与精子总数、精子浓度、精子活力和前向运动精子百分率均呈正相关（r值分别为0.227、0.215、0.111、0.120,P<0.05）。FSH与精子总数、精子浓度呈负相关（r值分别为-0.125、-0.236,P<0.05）。InhB与精子总数、精子浓度呈正相关（r值分别为0.232、0.166,P<0.05）。结论检测血清AMH、FSH、InhB能为不育症的诊治提供有价值的信息。

关键词: 抗米勒管激素, 抑制素B, 卵泡刺激素, 精子参数, 梗阻性无精子症, 非梗阻性无精子症

Abstract:

Objective To analyze the relationship between serum anti-Müllerian hormone（AMH）,follicle-stimulating hormone（FSH） and inhibin B（InhB）and sperm parameters,and to investigate the roles of serum AMH,FSH and InhB in the diagnosis of male infertility. Methods According to the results of sperm parameters and testicular biopsy,97 patients were classified into obstructive azoospermia（15 cases）,non-obstructive azoospermia（12 cases） and oligoasthenospermia（70 cases）,and 122 males with qualified semen quality were enrolled as control group. The total sperm count,sperm concentration,sperm motility,forward movement sperm rate and serum AMH,FSH and InhB were analyzed for their correlations. Results Compared with control group and obstructive azoospermia group,serum levels of AMH,FSH and InhB in non-obstructive azoospermia and oligoasthenospermia had statistical significance（P<0.05）. AMH was positively correlated with total sperm count,sperm concentration,sperm motility and forward movement sperm rate（r=0.227,0.215,0.111 and 0.120,P<0.05）. FSH was negatively correlated with total sperm count and sperm concentration（r=-0.125 and -0.236,P<0.05）. There were positive correlations between InhB and total sperm count,sperm concentration（r=0.232 and 0.166,P<0.05）. Conclusions The determinations of serum AMH,FSH and InhB can provide a reference for the diagnosis and treatment of male infertility.

Key words: Anti-Müllerian hormone;, Inhibin B, Follicle-stimulating hormone, Sperm parameter, Obstructive azoospermia, Non-obstructive azoospermia

中图分类号:

R446.69

刘秀菊, 李高驰, 阳红梅, 林建春. 血清AMH、FSH、InhB与精子参数的相关性分析[J]. 检验医学, 2021, 36(10): 1047-1049.

LIU Xiuju, LI Gaochi, YANG Hongmei, LIN Jianchun. Relationship between serum AMH,FSH,InhB and sperm parameters[J]. Laboratory Medicine, 2021, 36(10): 1047-1049.

图/表 2

参考文献 15

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组别	例数	AMH/（ng/mL）	FSH/（U/L）	InhB/（ng/mL）
梗阻性无精子症组	15	8.91±3.75	4.21±2.15	135.65±41.25
非梗阻性无精子症组	12	6.23±2.95^*	5.94±2.55^*	86.54±27.65^*
少弱精子症组	70	7.45±3.14^*	5.26±2.98^*	95.39±31.45^*
对照组	122	9.13±3.15	4.15±2.37	157.76±57.23

组别	例数	AMH/（ng/mL）	FSH/（U/L）	InhB/（ng/mL）
梗阻性无精子症组	15	8.91±3.75	4.21±2.15	135.65±41.25
非梗阻性无精子症组	12	6.23±2.95^*	5.94±2.55^*	86.54±27.65^*
少弱精子症组	70	7.45±3.14^*	5.26±2.98^*	95.39±31.45^*
对照组	122	9.13±3.15	4.15±2.37	157.76±57.23

血清AMH、FSH、InhB与精子参数的相关性分析

Relationship between serum AMH,FSH,InhB and sperm parameters

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Metrics

项目	精子总数		精子浓度		精子活力		前向运动精子百分率
项目	r值	P值	r值	P值	r值	P值	r值	P值
AMH	0.227	0.026	0.215	0.037	0.111	0.012	0.120	0.022
FSH	-0.125	0.031	-0.236	0.015	-0.008	0.072	-0.060	0.122
InhB	0.232	0.028	0.166	0.035	0.025	0.102	0.020	0.252

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