关键词: 凝血功能, 新生儿, 婴幼儿, 参考区间

Abstract:

Objective To establish the reference intervals of coagulation function in 0-3-year-old children. Methods Coagulation function was determined in 966 children of 0-3-year-old. The children were required without fever,inflammation,hematological diseases,digestive diseases,respiratory diseases,endocrine diseases,tumor or other genetic diseases and with normal growth. Prothrombin time（PT）,prothrombin time international normalized ratio（PT-INR）,activated partial thromboplastin time（APTT）,fibrinogen（Fib） and thrombin time（TT） were determined. According to age,the 966 children were classified into perinatal newborn （0-7 d）,newborn（8-30 d）,infant 1（1-6 months）,infant 2（7-12 months）,child 1（1-2 years） and child 2（2-3 years） groups. The parameters were analyzed statistically,and the reference intervals were evaluated. Results PT showed no statistical significance between 1-6 months and 7-12 months and between 1-2 years and 2-3 years old groups（P>0.05）. PT were 12.20-15.08s for 0-7 d,11.84-14.20s for 8-30 d,11.05-13.45s for 1-12 months and 10.92-12.68s for 1-3 years. PT-INR were 1.07-1.45 for 0-7 d,0.99-1.27 for 8-30 d,0.82-1.10 for 1-12 months and 0.83-1.10 for 1-3 years. APTT showed no statistical significance between 0-7 d and 8-30 d,between 7-12 months and 1-2 years and between 7-12 months and 2-3 years old groups（P>0.05）. APTT were 21.27-58.20s for 0-30 d,24.67-51.52s for 1-6 months and 24.01-43.73s for 7 months-3 years. Fib showed no statistical significance between 8-30 d and 1-6 months,between 7-12 months and 1-2 years and between 7-12 months and 2-3 years old groups（P>0.05）. Fib were 1.43-3.97g/ L for 0-7 d,1.58-3.72g/L for 8 d-6 months and 2.65-3.89g/L for 7 months-3 years. TT showed no statistical significance between 0-7 d and 8-30 d,between 0-7 d and 1-6 months,between 7-12 months and 1-2 years and between 7-12 months and 2-3 years old groups（P>0.05）. TT were 15.31-24.83s for 0 d-6 months and 15.83-23.39s for 7 months-3 years. Conclusions Children's coagulation function is in a continuous growing process. There are physiological changes for each parameter of coagulation function. Laboratories should establish suitable reference intervals according to age,in order to provide a reference for clinical diagnosis and treatment of coagulation system diseases,preoperative examination and anticoagulant monitoring.

Key words: Coagulation function, Newborn, Infant, Reference interval