糖化血红蛋白标准化和检测准确度现状

doi:10.3969/j.issn.1673-8640.2016.05.001

摘要/Abstract

摘要：

糖化血红蛋白A_1c（HbA_1c）是诊断糖尿病和监测其治疗效果的重要指标。在国际临床化学与检验医学联合会（IFCC）定义了HbA_1c的被测量之后,经过各方的努力,全球各临床实验室HbA_1c检测结果间的差异正逐步减小。所有提供HbA_1c检测产品的厂商都不会客观地描述自己产品的弱点,只会强调其优点和临床价值。面对HbA_1c检测的现状,临床实验室必须充分了解每个产品的特性及其不足之处,在将产品用于临床检测前必须验证产品的分析性能。只有确认其分析性能能够用于临床检测时,才能使用。一个实验室内必须具备2种不同检测方法的产品,这样才能识别患者样品内有无异常血红蛋白。目前,尽管人们认为免疫学方法检测HbA_1c时无异常血红蛋白的干扰,但国际上尚未从临床上对各种异常血红蛋白的影响作出客观的判断。为了患者的利益,临床实验室一定要充分了解更多的信息。

关键词: 糖化血红蛋白, 标准化, 准确度

Abstract:

Glycated hemoglobin A_1c（HbA_1c） is an important parameter for the diagnosis of diabetes mellitus and monitoring treatment efficiency. After HbA_1c measurand being defined by the International Federation of Clinical Chemistry and Laboratory Medicine （IFCC）,with efforts,the differences are decreasing gradually among clinical laboratories in the world. Although HbA_1c manufacturers introduce their instruments' advantages and clinical significance mainly,instead of weaknesses,clinical laboratories should know instruments' characteristics and disadvantages. Instruments can be used into clinical determinations,only when the analysis performances have been verified and satisfy clinical application. Every laboratory should use 2 different methods,which can identify whether there is abnormal hemoglobin or not. Although HbA_1c can be determined by immunological methods without interference from abnormal hemoglobin,the influence of abnormal hemoglobin has not been defined. In short,clinical laboratories should learn as much information as possible for patients.

Key words: Glycated hemoglobin A1c, Standardization, Accuracy

中图分类号:

R446.1

冯仁丰. 糖化血红蛋白标准化和检测准确度现状[J]. 检验医学, 2016, 31(5): 345-349.

FENG Renfeng. Standardization of glycated hemoglobin A_1c determination and its accuracy[J]. Laboratory Medicine, 2016, 31(5): 345-349.

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