Survivin及c-myc基因在肾癌组织中的表达及其相关性研究

doi:10.3969/j.issn.1673-8640.2014.07.016

检验医学 ›› 2014, Vol. 29 ›› Issue (7): 760-763.DOI: 10.3969/j.issn.1673-8640.2014.07.016

Survivin及c-myc基因在肾癌组织中的表达及其相关性研究

张则嵘¹，赵俊岭²，顾丹今³，刘军⁴，杨磊⁵

1.新疆库尔勒市人民医院肾病科，新疆库尔勒 841000；
2.新疆医科大学研究生院，新疆乌鲁木齐 830011；
3.新疆医科大学基础医学院形态中心，新疆乌鲁木齐 830011；
4.新疆医科大学第五附属医院泌尿外科，新疆乌鲁木齐 830011；
5.新疆维吾尔自治区中医院泌尿外科，新疆乌鲁木齐 830011

收稿日期:2013-06-13 出版日期:2014-07-30 发布日期:2014-07-21
通讯作者: 赵俊岭，联系电话:0991-4365220。
作者简介:张则嵘，男，1972年生，学士，主治医师，主要从事泌尿系统恶性肿瘤的发病机制研究。

The expression and relation studies of Survivin and c-myc in renal cell carcinoma tissue

ZHANG Zerong¹,ZHAO Junling²,GU Danjin³,LIU Jun⁴,YANG Lei⁵

1. Department of Nephrology, Kuerle People′s Hospital, Xinjiang Kuerle 841000, China;
2. Graduate School, Xinjiang Medical University, Xinjiang Urumqi 830011, China;
3. Morphological Center, Xinjiang Medical University Basic Medical School, Xinjiang Urumqi 830011, China;
4. Department of Urinary Surgery, the Fifth Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830011, China;
5. Department of Urinary Surgery, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Xinjiang Urumqi 830011 , China

Received:2013-06-13 Online:2014-07-30 Published:2014-07-21

摘要/Abstract

摘要：

目的　探讨肾癌组织中Survivin、c-myc基因的表达及临床意义。方法　采用逆转录-聚合酶连反应（RT-PCR）、免疫印迹法检测34例肾癌标本中Survivin、c-myc的表达，分析这2个基因与临床病理特征的关系。结果　肾癌组织中Survivin、c-myc基因的表达水平明显高于癌旁正常组织（P＜0.01）。Survivin基因的表达与临床分期、淋巴结转移有关（P＜0.05）， c-myc基因的表达与分化程度有关（P＜0.05）。Survivin、c-myc之间的表达呈正相关（r=0.446，P＜0.01）。结论　肾癌组织中Survivin、c-myc基因表达上调，可能参与了肾癌的发生、发展。

关键词: Survivin基因, c-myc基因, 肾癌

Abstract:

Objective　To study the expressions of Survivin and c-myc in renal cell carcinoma tissue and their clinical significance. Methods　By reverse transcription polymerase chain reaction（RT-PCR） and Western-blot， the expressions of Survivin and c-myc were determined in 34 renal cell carcinoma specimens. The relationship of the 2 genes and clinical pathological characteristics were analyzed. Results　The expressions of Survivin and c-myc in renal cell carcinoma tissue were higher than those in normal tissues with statistical significance（P＜0.01）. The expression of Survivin was significantly related to the clinical stage and lymphonode metastasis（P＜0.05）. The expression of c-myc was significantly related to the degrees of pathological differentiation（P＜0.05）.The expression of Survivin in renal cell carcinoma tissue was positively related to the expression of c-myc（r=0.446， P＜0.01）. Conclusions　The overexpression of Survivin and c-myc could have important roles in the carcinogenesis and development of renal cell carcinoma.

Key words: Survivin, c-myc, Renal cell carcinoma

中图分类号:

Q503

张则嵘，赵俊岭，顾丹今，刘军，杨磊. Survivin及c-myc基因在肾癌组织中的表达及其相关性研究[J]. 检验医学, 2014, 29(7): 760-763.

ZHANG Zerong,ZHAO Junling,GU Danjin,LIU Jun,YANG Lei. The expression and relation studies of Survivin and c-myc in renal cell carcinoma tissue[J]. , 2014, 29(7): 760-763.

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Survivin及c-myc基因在肾癌组织中的表达及其相关性研究

The expression and relation studies of Survivin and c-myc in renal cell carcinoma tissue

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