自噬与缺血再灌注损伤

doi:10.3969/j.issn.1673-8640.2014.02.022

检验医学 ›› 2014, Vol. 29 ›› Issue (2): 182-185.DOI: 10.3969/j.issn.1673-8640.2014.02.022

自噬与缺血再灌注损伤

张文静, 崔丽艳, 张捷

北京大学第三医院检验科, 北京 100191

收稿日期:2013-01-04 出版日期:2014-02-20 发布日期:2014-02-20
通讯作者: 张捷, 联系电话:010-82265719
作者简介:张文静, 女, 1980年生, 主管技师, 主要从事细胞自噬在缺血再灌注损伤中发挥的作用及机制研究。
基金资助:
国家自然科学基金面上项目(81271903)

Autophagy and ischemia/reperfusion injury

ZHANG Wenjing, CUI Liyan, ZHANG Jie.

Department of Clinical Laboratory, the Third Hospital of Peking University, Beijing 100191, China

Received:2013-01-04 Online:2014-02-20 Published:2014-02-20

摘要/Abstract

摘要： 自噬是存在于真核细胞生物中的一种细胞自我吞噬的现象。在生理状态下, 可以维持机体内环境的稳定。在多种疾病的发生过程中, 自噬也发挥重要作用。实验证明在缺血再灌注损伤的整个过程中, 均有自噬的参与, 但在缺血阶段和再灌注阶段, 自噬有可能发挥不同的作用。在缺血阶段, 自噬发挥保护细胞的作用, 而在再灌注阶段, 自噬可能会进一步加重细胞损伤甚至导致细胞死亡。

关键词: 自噬, 缺血/再灌注损伤

Abstract: Autophagy is the phenomenon that cell phagocytose itself in eukaryotic organism. In physiological condition, autophagy can maintain the stability of environment in vivo. Autophagy plays an important role in the process of many diseases. Studies prove that autophagy participates in the process of ischemia/reperfusion injury. However, it may play different roles in the 2 processes. In the process of ischemia, autophagy can protect cells, while in the process of reperfusion, autophagy may aggravate cell injury and even lead to cell death.

Key words: Autophagy, Ischemia/reperfusion injury

中图分类号:

R446.11

张文静, 崔丽艳, 张捷. 自噬与缺血再灌注损伤[J]. 检验医学, 2014, 29(2): 182-185.

ZHANG Wenjing, CUI Liyan, ZHANG Jie.. Autophagy and ischemia/reperfusion injury[J]. , 2014, 29(2): 182-185.

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自噬与缺血再灌注损伤

Autophagy and ischemia/reperfusion injury

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