c-jun、c-fos、BCL-2A基因的功能和铅对其影响

doi:10.3969/j.issn.1673-8640.2014.02.020

检验医学 ›› 2014, Vol. 29 ›› Issue (2): 174-177.DOI: 10.3969/j.issn.1673-8640.2014.02.020

c-jun、c-fos、BCL-2A基因的功能和铅对其影响

刘康生¹, 曹小莉², 钟天鹰³, 李希翎⁴, 顾平清¹

1. 南京医科大学附属南京妇幼保健医院检验科, 江苏南京 210004;
2. 南京鼓楼医院检验科, 江苏南京 210008;
3. 南京医科大学附属南京妇幼保健医院院办, 江苏南京 210004;
4. 南京医科大学附属南京妇幼保健医院儿童保健科, 江苏南京 210004

收稿日期:2013-01-28 出版日期:2014-02-20 发布日期:2014-02-20
通讯作者: 顾平清, 联系电话:025-52226777
作者简介:刘康生, 男, 1979年生, 硕士, 主管技师, 主要从事微量元素与铅研究、铅与信号传导的研究。

The functions of c-jun, c-fos and BCL-2A genes and the influence of lead on them

LIU Kangsheng¹, CAO Xiaoli², ZHONG Tianying³, LI Xiling⁴, GU Pingqing¹.

1. Department of Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Jiangsu Nanjing 210004, China; 2. Department of Clinical Laboratory, Nanjing Drum Tower Hospital, Jiangsu Nanjing 210008, China; 3. Department of Admin Office, Nanjing Maternity and Child Health Care Hospital, Jiangsu Nanjing 210004, China; 4. Department of Health, Nanjing Maternity and Child Health Care Hospital, Jiangsu Nanjing 210004, China

Received:2013-01-28 Online:2014-02-20 Published:2014-02-20

摘要/Abstract

摘要： 在原癌基因家族中有一类能被第二信使所诱导的基因称为即刻早期基因(IEGs)。IEGs是用丝裂原处理静止细胞时快速诱导的基因类。以c-fos和c-jun为代表的即早基因(IEG)是一类可被第二信使诱导激活的原癌基因^[1], 具有把短时程作用的细胞外信号和细胞功能的长时程改变偶联起来的效应, 是用丝裂原处理静止细胞时快速诱导的基因类。这类基因是细胞经外部刺激后最先表达的一组基因, 是联系细胞生化改变与细胞最终对刺激发生特异性反应的中介物。IEGs 编码特异的DNA结合蛋白, 影响靶基因转录率并参与细胞内信息的传递, 将短暂的信号转为长时程的反应。因此, IEGs又被认为是第三信使。IEGs主要包括 c-fos、c-jun、c-myc和 egr家族。IEGs的表达与突触活动相关并在长期记忆形成和巩固的神经机制中有重要作用。研究证明多种IEGs的表达在记忆的巩固和神经可塑性机制中有十分重要的作用。

关键词: 即早基因, 表达, 铅, 学习记忆

Abstract: Immediate-early genes (IEG) are one of the proto-oncogene families which can be induced by second messenger genes, belonging to the rapidly induced genes when treated with static cell mitogen. Such as c-fos and c-jun, which can be activated by second messenger, can produce the coupling effect of the short-term effects of extracellular signals and the long-term changes of cell function. These genes are firstly expressed after external stimuli, are the mediator linking cell biochemical changes to cell eventually specifically reacting to stimuli. IEGs encode the specific DNA binding proteins, affect the rate of transcription of target genes, involve in the intracellular signal transmission, and convert transient signals into long-time course reaction. Therefore, IEGs are considered as the third messengers. Currently, IEGs mainly include c-fos and c-jun family, c-myc and egr families. The expression of IEGs is related to the synaptic activity, and plays an important role in formation of long-term memory and consolidation of neural mechanisms. Studies have demonstrated that the expression of many IEGs has a very important role in consolidation of memory and neural plasticity mechanisms.

Key words: Immediate-early gene, Expression, Lead, Learning memory

中图分类号:

Q503

刘康生, 曹小莉, 钟天鹰, 李希翎, 顾平清. c-jun、c-fos、BCL-2A基因的功能和铅对其影响[J]. 检验医学, 2014, 29(2): 174-177.

LIU Kangsheng, CAO Xiaoli, ZHONG Tianying, LI Xiling, GU Pingqing.. The functions of c-jun, c-fos and BCL-2A genes and the influence of lead on them[J]. , 2014, 29(2): 174-177.

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c-jun、c-fos、BCL-2A基因的功能和铅对其影响

The functions of c-jun, c-fos and BCL-2A genes and the influence of lead on them

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