Progress of thrombin-activatable fibrinolysis inhibitor determination in clinical application

doi:10.3969/j.issn.1673-8640.2024.10.016

Abstract

Abstract:

Thrombin-activatable fibrinolysis inhibitor（TAFI）is a single chain glycoprotein with plasma carboxypeptidase-like activity，which is synthesized and secreted mainly by the liver，and it exists in plasma in the form of zymogen. The traditional methods of TAFI deterimination include enzyme-linked immunosorbent assay（ELISA），enzymatic assay and functional assay. In the recent years，new determination methods，such as immunoturbidimetry and isotope dilution mass spectrometry，have been developed and popularized，promoting the clinical application of TAFI in deep vein thrombosis，cardiovascular and cerebrovascular diseases，hemorrhagic diseases and inflammatory diseases. This review introduces the physiological function of TAFI，summarizes the determination technologies and determination principles of TAFI，and it reviews the clinical application value of TAFI，aiming to understand the role of TAFI for thrombotic diseases and provide a reference for prevention and treatment.

Key words: Thrombin-activatable fibrinolysis inhibitor, Determination, Clinical application, Experimental diagnosis

CLC Number:

R446.11

CUI Weiqi, OU Xinyang, ZHAO Chunhe, XIA Wei, QU Linlin. Progress of thrombin-activatable fibrinolysis inhibitor determination in clinical application[J]. Laboratory Medicine, 2024, 39(10): 1021-1026.

Figures/Tables 1

References 50

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