Laboratory Medicine ›› 2024, Vol. 39 ›› Issue (6): 568-572.DOI: 10.3969/j.issn.1673-8640.2024.06.009

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Prognosis evaluation model of children with Mycoplasma pneumoniae pneumonia based on MP DNA and peripheral blood inflammation indicators

DAI Yao1, LI Jiahui1(), XU Xiuhong2   

  1. 1. Jinshan Hospital of Fudan University,Shanghai 201508,China
    2. Shanghai Minhang Mental Health Center,Shanghai 201112,China
  • Received:2023-12-25 Revised:2024-03-25 Online:2024-06-30 Published:2024-07-08

Abstract:

Objective To evaluate the clinical value of a model for the prognosis of children with Mycoplasma pneumoniae(MP) pneumonia(MPP) based on MP DNA and peripheral blood inflammation indicators. Methods Totally,139 children with MMP were enrolled from Jinshan Hospital of Fudan University from November to December 2023. The general clinical data were collected,and MP DNA,C-reactive protein(CRP),procalcitonin(PCT) and blood routine test indicators were determined before treatment. Neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR) and monocyte-to-lymphocyte ratio(MLR) were calculated. According to the prognosis after 1 month of treatment,they were classified into poor prognosis group(33 cases) and good prognosis group(106 cases). Spearman correlation analysis was used to evaluate the correlation between various indicators and poor prognosis of MPP. Multivariate Logistic regression analysis was used to evaluate the influence factors of poor prognosis in children with MPP. Receiver operating characteristic(ROC) curve was used to evaluate the efficacy of single and combined determinations of each indicator in determining poor prognosis of children with MPP. Results The levels of MP DNA,CRP,NLR and PLR in poor prognosis group were higher than those in good prognosis group(P<0.05),but there was no statistical significance in PCT and MLR between the 2 groups(P>0.05). MP DNA,CRP,NLR and PLR were positively correlated with poor prognosis in MPP children(r values were 0.313,0.225,0.277 and 0.262,P<0.05). MP DNA,CRP,NLR and PLR were all risk factors for poor prognosis in MPP children(P<0.05). The areas under curves(AUC) of single determinations of MP DNA,CRP,NLR and PLR and combined determination to determine the poor prognosis of MPP children were 0.799,0.724,0.775,0.732 and 0.935,respectively. Conclusions Both MP DNA and inflammation indicators of MPP children show abnormal changes before treatment,and the prognosis evaluation model has good clinical application value.

Key words: Mycoplasma pneumoniae, C-reactive protein, Procalcitonin, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Monocyte-to-lymphocyte ratio, Mycoplasma pneumoniae pneumonia, Children, Prognosis

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