Clinical value of serum lipoprotein-related phospholipase A2 combined with superoxide dismutase in predicting mild cognitive impairment in cerebral small vessel disease patients

doi:10.3969/j.issn.1673-8640.2022.010.06

Abstract

Abstract:

Objective To evaluate the clinical value of serum lipoprotein-related phospholipase A2（Lp-PLA2） combined with superoxide dismutase（SOD） in predicting mild cognitive impairment （MCI）in cerebral small vessel disease（CSVD）. Methods According to the Montreal Cognitive Assessment（MoCA） score at admission，a total of 120 patients with CSVD were enrolled and classified into MCI group（MoCA score <26） and control group（MoCA score ≥26）. The general information and past medical history of the patients were collected，and plasma Lp-PLA2 and SOD levels were determined. Pearson correlation analysis was used to evaluate the correlation between Lp-PLA2，SOD and MoCA score. Multivariate Logistic regression analysis was used to evaluate the risk factors for MCI. Receiver operating characteristic（ROC） curve was used to evaluate the values of Lp-PLA2 and SOD in the auxiliary diagnosis of MCI. Results The level of Lp-PLA2 in MCI group was higher than that in control group（P<0.05），and the level of SOD was lower than that in control group（P<0.05）. Multivariate Logistic regression analysis showed that Lp-PLA2 [odds ratio（OR）=3.241，95% confidence interval（CI） 2.014-5.362] were independent risks of MCI，and SOD（OR=0.652，95%CI 0.407-0.964） was an independent protective factor for MCI. Lp-PLA2 was negatively correlated with MoCA score（r=-0.535，P=0.017），and SOD was positively correlated with MoCA score（r=0.684，P=0.008）. The areas under curves（AUC） of Lp-PLA2，SOD single determinations and combined determination in the diagnosis of MCI were 0.813，0.738 and 0.903，respectively，and the efficiency of combined determination was better than those of single determinations（P<0.05）. Conclusions Lp-PLA2 and SOD are influence factors for MCI in CSVD patients，and the combined determination may play a role in the diagnosis of MCI.

Key words: Lipoprotein-related phospholipase A2, Superoxide dismutase, Cerebral small vessel disease, Mild cognitive impairment

MAN Chunlu, YANG Qingsong. Clinical value of serum lipoprotein-related phospholipase A2 combined with superoxide dismutase in predicting mild cognitive impairment in cerebral small vessel disease patients[J]. Laboratory Medicine, 2022, 37(10): 939-943.

Figures/Tables 4

References 21

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组别	例数	年龄/岁	性别		BMI/ （kg/m²）	吸烟/ [例（%）]	饮酒/ [例（%）]
组别	例数	年龄/岁	男/例	女性/例	BMI/ （kg/m²）	吸烟/ [例（%）]	饮酒/ [例（%）]
对照组	55	61.21±7.17	34	21	24.34±3.16	25（45.45）	32（58.18）
MCI组	65	59.64±6.13	36	29	23.83±2.52	42（64.62）	36（55.38）
统计值		2.421	0.507		2.120	4.435	0.095
P值		0.073	0.496		0.080	0.035	0.758
组别	高血压/ [例（%）]	糖尿病/ [例（%）]	高脂血症/ [例（%）]	冠心病/ [例（%）]	文化程度/[例（%）]
组别	高血压/ [例（%）]	糖尿病/ [例（%）]	高脂血症/ [例（%）]	冠心病/ [例（%）]	初中及以下	高中	大学及以上
对照组	23（41.82）	29（52.73）	30（54.55）	36（65.45）	17（30.91）	24（43.64）	14（25.45）
MCI组	45（69.23）	36（55.38）	37（66.92）	36（55.38）	23（35.38）	26（40.00）	16（24.62）
统计值	9.117	0.085	0.068	1.259	0.282
P值	0.003	0.771	0.794	0.262	0.869

组别	例数	年龄/岁	性别		BMI/ （kg/m²）	吸烟/ [例（%）]	饮酒/ [例（%）]
组别	例数	年龄/岁	男/例	女性/例	BMI/ （kg/m²）	吸烟/ [例（%）]	饮酒/ [例（%）]
对照组	55	61.21±7.17	34	21	24.34±3.16	25（45.45）	32（58.18）
MCI组	65	59.64±6.13	36	29	23.83±2.52	42（64.62）	36（55.38）
统计值		2.421	0.507		2.120	4.435	0.095
P值		0.073	0.496		0.080	0.035	0.758
组别	高血压/ [例（%）]	糖尿病/ [例（%）]	高脂血症/ [例（%）]	冠心病/ [例（%）]	文化程度/[例（%）]
组别	高血压/ [例（%）]	糖尿病/ [例（%）]	高脂血症/ [例（%）]	冠心病/ [例（%）]	初中及以下	高中	大学及以上
对照组	23（41.82）	29（52.73）	30（54.55）	36（65.45）	17（30.91）	24（43.64）	14（25.45）
MCI组	45（69.23）	36（55.38）	37（66.92）	36（55.38）	23（35.38）	26（40.00）	16（24.62）
统计值	9.117	0.085	0.068	1.259	0.282
P值	0.003	0.771	0.794	0.262	0.869

组别	例数	TC/（mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）	CRP/（mmol/L）
对照组	55	5.21±0.25	0.95±0.15	2.75±0.87	5.73±0.96
MCI组	65	5.15±0.34	0.83±0.24	2.82±0.75	6.32±0.74
t值		1.071	0.941	1.265	3.745
P值		0.226	0.358	0.184	0.013

组别	例数	TC/（mmol/L）	HDL-C/（mmol/L）	LDL-C/（mmol/L）	CRP/（mmol/L）
对照组	55	5.21±0.25	0.95±0.15	2.75±0.87	5.73±0.96
MCI组	65	5.15±0.34	0.83±0.24	2.82±0.75	6.32±0.74
t值		1.071	0.941	1.265	3.745
P值		0.226	0.358	0.184	0.013

因素	β值	标准误	Wald值	OR值（95%CI）	P值
吸烟	0.647	0.426	2.307	1.305（0.984~1.985）	0.096
高血压	0.965	0.652	2.190	1.051（0.947~1.564）	0.102
CRP	1.847	1.425	1.680	1.063（0.947~1.652）	0.104
Lp-PLA2	2.325	1.925	1.459	3.241（2.014~5.362）	0.008
SOD	-0.762	0.504	2.494	0.652（0.407~0.964）	0.020