Abstract:

Objective To investigate the diagnostic value of prostate-specific antigen isoform 2（p2PSA）,prostate-specific antigen isoform 2 percentage（p2PSA%） and prostate health index（PHI） in the identification of benign and malignant prostate diseases.Methods A total of 250 male patients who underwent transrectal ultrasound-guided prostate biopsy were enrolled and classified into benign prostate disease group（145 cases） and prostate cancer group（105 cases） based on the pathological results,and they were classified into ≤65 years old and >65 years old groups according to ages. Total prostate-specific antigen（t-PSA）,free prostate-specific antigen（f-PSA） and p2PSA were determined in serum samples from all the patients,and free prostate-specific antigen percentage（f-PSA%）,p2PSA% and PHI were calculated. The efficiency of each index in the diagnosis of prostate cancer was evaluated by receiver operating characteristic（ROC） curve. Results Compared with benign prostate disease group,the t-PSA,p2PSA,p2PSA% and PHI of prostate cancer group were increased（P<0.01,P<0.001）,and f-PSA% was decreased（P<0.001）. There was no statistical significance in f-PSA between the 2 groups（P>0.05）. ROC curve analysis results showed that,in ≤65 years old patients,the areas under curves（AUC） of t-PSA,f-PSA,f-PSA %,p2PSA,p2PSA% and PHI in the diagnosis of prostate cancer were 0.687,0.500,0.792,0.815,0.795 and 0.892,respectively. In >65 years old patients,the AUC of t-PSA,f-PSA,f-PSA %,p2PSA,p2PSA% and PHI in the diagnosis of prostate cancer were 0.748,0.542,0.900,0.780,0.843 and 0.929,respectively.Conclusions The diagnostic efficiency of prostate cancer markers differs in different ages. Prostate cancer markers,PHI,p2PSA and p2PSA%,can improve the differential diagnosis of benign and malignant prostate diseases.

Key words: Prostate-specific antigen isoform 2, Prostate-specific antigen, Prostate cancer