Research progress on neutrophil extracellular traps in ulcerative colitis

doi:10.3969/j.issn.1673-8640.2020.06.023

Abstract

Abstract:

Ulcerative colitis（UC） is an autoimmune disease associated with chronic bowel inflammation,the pathogenesis of UC is unclear,but its etiology is multifactorial,and the incidence of UC is increasing. Neutrophil granulocytes play roles in the immune response of humans and are the first cells to migrate to the site of inflammation. Traditionally,neutrophils defend the host against pathogens,the important functions of neutrophils include chemotaxis,phagocytosis and degranulation. Recent massive data support that neutrophils were found to have a specific mechanism of immune defense by forming neutrophil extracellular traps（NET）. NET not only play a defense reaction but also are related to the pathogenesis of various kinds of diseases,including autoimmune diseases. Investigating the relationship of NET in the development of autoimmune diseases will further help with understanding the etiology and pathogenesis of autoimmune diseases. This review focuses on the role of NET in the pathogenesis of UC,in order to provide a reference for the therapy and diagnosis of UC.

Key words: Ulcerative colitis, Neutrophil, Neutrophil extracellular trap, Autoimmune disease

CLC Number:

R446.1

LUO Ting, PAN Xiujun. Research progress on neutrophil extracellular traps in ulcerative colitis[J]. Laboratory Medicine, 2020, 35(6): 626-630.

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