Abstract:

Objective To observe the characteristics of blood routine items,biochemical indexes and D-dimer（DD） of general and severe corona virus disease 2019（COVID-19） patients and in the treatment of severe COVID-19,and to provide a reference for COVID-19 clinical diagnosis and treatment. Methodse Totally,296 COVID-19 patients were analyzed retrospectively. A total of 100 patients with common pneumonia were enrolled as control group. The changes of blood routine items,biochemical indexes and DD in 30 severe COVID-19 patients were analyzed dynamically. Results In severe COVID-19 group,lymphocyte percentage（LYMPH%）,the absolute value of lymphocyte（LYMPH#） and platelet（PLT） count were lower than those in general COVID-19 group（P<0.05）. The absolute value of neutrophil（NEUT#）,neutrophil/lymphocyte ratio（NLR）,aspartate aminotransferase（AST）,urea,creatine kinase（CK）,lactate dehydrogenase（LDH） and DD were higher than those in general COVID-19 group（P<0.05）. In severe COVID-19 group,white blood cell（WBC） count,PLT count,NEUT#,LYMPH#,LYMPH% were lower than those in control group,and NLR and LDH were higher（P<0.05）. Compared with control group,in general COVID-19 group,WBC count,PLT count,NEUT#,NLR,LYMPH#,urea,CK,DD and LDH were lower,and LYMPH% were higher（P<0.05）. There were 7 of 30 severe cases aggravated or turned to critical state,and their WBC count,NEUT# and NLR were higher than normal levels,while LYMPH# was lower than normal level. The above indexes in 23 patients who were improved or virus nucleic acid turned negative were gradually recovered to normal levels. Conclusions Blood routine items,biochemical indexes and DD are important for the diagnosis and treatment of COVID-19.

Key words: Blood routine item, Biochemical index, D-dimer, Corona virus disease 2019, Severe