Abstract:

Objective To investigate the correlation between neonatal hypoxic-ischemic encephalopathy（HIE） and neurobehavior with S100B protein and neuron-specific enolase（NSE）. Methodse A total of 68 children with HIE were enrolled. They were classified into severe HIE group（20 cases）,moderate HIE group（25 cases） and mild HIE group（23 cases）. Totally,25 healthy newborns were enrolled as healthy control group. Serum S100B protein and NSE levels,neonatal behavioral neurological assessment（NBNA） score and NBNA score abnormality rate were determined. The changes of serum NSE and S100B protein in HIE group at 24 h,48 h,72 h and 7 d after birth were observed dynamically. Results In healthy control group,mild HIE group,moderate HIE group,severe HIE group,S100B protein and NSE levels and NBNA score abnormality rate were successively increased,and NBNA score was successively decreased（P<0.001）. Serum S100B protein and NSE levels were negatively correlated with NBNA score（r=-0.243 and -0.542,respectively,P<0.001）,and they were positively correlated with HIE severity（r=0.398 and 0.476,respectively,P<0.001）. With the extension of birth time,serum S100B protein and NSE levels in severe HIE group,moderate HIE group and mild HIE group were gradually decreased（P<0.001）. Serum S100B protein and NSE levels in mild HIE group,moderate HIE group and severe HIE group were successively increased at the same time point（P<0.001）. Conclusions Serum S100B protein and NSE levels are correlated with the severity of HIE and the neurobehavior of children,which can be used for the early diagnosis and prognosis of HIE.

Key words: S100B protein, Neuron-specific enolase, Neurobehavior, Neonatal hypoxic-ischemic encephalopathy