Etiological analysis of children with hand,foot and mouth disease in Dali Prefecture from 2013 to 2017

doi:10.3969/j.issn.1673-8640.2019.07.002

Abstract

Abstract:

Objective To understand the etiological characteristics of children with hand,foot and mouth disease in Dali Prefecture from 2013 to 2017,and to provide a reference for its prevention and control. Methods The epidemiological data and the clinical specimens of 2 873 children with hand,foot and mouth disease from medical institutions in Dali Prefecture were collected from 2013 to 2017. All the subjects were classified according to years,specimen types,sex,regions,months and ages. Enterovirus 71（EV71）,coxsackievirus A16（CoxA16） and other enteroviruses（EV）were determined by real-time fluorescence quantitation polymerase chain reaction（PCR）. Results There was statistical significance for EV71,CoxA16 and other EV classifying according to years,specimen types,ages,regions and months（χ²=893.68,121.18,41.07,354.25 and 240.33,P<0.05）. The determination rates of EV71 and CoxA16 in 3-5-year-old group were the highest among age groups,which were 25.1% and 23.3%,respectively. EV71 was determined mainly in spring,and CoxA16 and other EV were determined mainly in summer. There was no statistical significance for the determination rates of other EV,EV71 and CoxA16 between males and females（χ²=2.66,P>0.05）. Conclusions Strengthening pathogen surveillance is a scientific means on preventing and controlling hand,foot and mouth disease.

Key words: Hand, foot and mouth disease, Real-time fluorescence quantitation polymerase chain reaction, Enterovirus 71, Coxsackievirus A16

CLC Number:

R725.1

DUAN Feiyun, CHEN Xiaoming, CHEN Ran. Etiological analysis of children with hand,foot and mouth disease in Dali Prefecture from 2013 to 2017[J]. Laboratory Medicine, 2019, 34(7): 583-586.

Figures/Tables 6

References 12

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年份	粪便样本			咽拭样本
年份	其他EV	EV71	CoxA16	其他EV	EV71	CoxA16
2013年	1.5	13.7	5.0	3.8	8.4	4.6
2014年	9.4	48.5	13.0	5.8	22.3	12.9
2015年	33.5	6.7	38.7	19.6	2.6	7.8
2016年	13.0	26.0	40.4	4.8	6.5	39.2
2017年	21.0	33.7	16.1	20.2	17.5	21.0
合计	14.9	23.7	21.8	11.0	11.5	17.2

年份	粪便样本			咽拭样本
年份	其他EV	EV71	CoxA16	其他EV	EV71	CoxA16
2013年	1.5	13.7	5.0	3.8	8.4	4.6
2014年	9.4	48.5	13.0	5.8	22.3	12.9
2015年	33.5	6.7	38.7	19.6	2.6	7.8
2016年	13.0	26.0	40.4	4.8	6.5	39.2
2017年	21.0	33.7	16.1	20.2	17.5	21.0
合计	14.9	23.7	21.8	11.0	11.5	17.2

组别	样本数	检出率
组别	样本数	EV71	CoxA16	其他EV
<1岁组	1 016	17.2	16.7	17.0
1~3岁组	1 229	19.4	22.0	12.9
3~5岁组	438	25.1	23.3	8.9
5~14岁组	190	20.5	21.1	10.0
合计	2 873	19.6	20.3	13.6

组别	样本数	检出率
组别	样本数	EV71	CoxA16	其他EV
<1岁组	1 016	17.2	16.7	17.0
1~3岁组	1 229	19.4	22.0	12.9
3~5岁组	438	25.1	23.3	8.9
5~14岁组	190	20.5	21.1	10.0
合计	2 873	19.6	20.3	13.6

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