Targeting inhibition on the overexpressed HRR proteins in cancer cells to enhance chemoradio-sensitivity

doi:10.3969/j.issn.1673-8640.2018.07.019

Abstract

Abstract:

Homologous recombination repair （HRR） is a prominent approach for repairing exogenous and endogenous DNA double-stranded breaks in mammalian cells,which can preserve genome integrity and stability to ensure the function and viability of mammalian cells. It has been widely recognized as a tumor suppressor. Recent studies have found that cancer cells with increased expression of HRR proteins hold powerful repair vitality,causing resistance to chemotherapies and radiotherapies by repairing DNA damage triggered by these curing methods,impeding cell apoptosis pathway and activating cell survival pathway,thus greatly promoting cancer cell survival. These overexpressed proteins play an oncogenic role in cancer cells,as indicate by maintaining genome stability of these cells and promoting tumorigenesis and tumor development,thereby providing potential targets of precision cancer therapy. Targeting inhibition through drugs on the overexpressed HRR proteins in cancer cells will not only stimulate cell apoptosis,but also remarkably enhance the cellular sensitivity to ionizing radiation and cytotoxic chemotherapies.

Key words: Homologous recombination repair protein, Oncogene, Tumor therapy

CLC Number:

R446.62

ZHU Jiabei, HUANG Nan, CUI Zhongqi, YANG Qingyuan, PAN Qiuhui. Targeting inhibition on the overexpressed HRR proteins in cancer cells to enhance chemoradio-sensitivity[J]. Laboratory Medicine, 2018, 33(7): 657-662.

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