Abstract:

Objective To understand the distribution characteristic and drug resistance of pathogens in patients with bloodstream infection from Shanghai Pudong Gongli Hospital,and to provide a reference on the choice of antimicrobial agents for treatment. Methods A total of 380 pathogens were isolated from inpatients with bloodstream infection in Shanghai Pudong Gongli Hospital from July 2012 to June 2015,and were identified using VITEK2 Compact automated microorganism analysis system. Drug susceptibility test was performed by VITEK2 Compact. The data were analyzed by WHONET 5.6 software.Results There were 157 isolates of Gram-positive cocci,accounted for 41.3%. Coagulase-negative Staphylococcus,Staphylococcus aureus andEnterococcus were main Gram-positive cocci. A total of 203 isolates of Gram-negative bacilli were isolated and identified,accounted for 53.4%,and Escherichia coli,Klebsiella pneumoniae andPseudomonas aeruginosa were main Gram-negative bacilli. There were 20 isolates of Candida,and Candida albicans was common. The drug resistance rate of Staphylococcus aureus to oxacillin was 47.6%. The drug resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem were 23.1% and 36.4%,and those of Escherichia coli and Klebsiella pneumoniae to ertapenem were 0.0% and 11.1%. The drug resistance rate of Candida albicans to fluconazole was 30.8%. Conclusions Coagulase-negative Staphylococcus and Escherichia coli are the most common pathogens causing bloodstream infection with high drug resistance rates. It should pay more attention to the rational use of antimicrobial agents.

Key words: Bloodstream infection, Pathogens, Drug resistance rate