Drug resistance of invasive fungi and its mechanisms

doi:10.3969/j.issn.1673-8640.2016.09.001

Abstract

Abstract:

A total of 4 original articles and 1 review about the drug resistance of invasive fungi and its mechanisms are collected for this special topic. The original articles and review describe the drug resistance and mechanisms of Candida albicans,Aspergillus fumigatus and Cryptococcus neoformans. While antifungal agents are widely used in recent years,the drug resistance of fungi increases gradually. It is useful to study the drug resistance mechanism of fungi and the new targets for antifungal agents. It can provide a reference for the research and development of new antifungal agents and the treatment with antifungal agents.

Key words: Invasive fungi, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, Drug resistance, Drug resistance mechanisms

CLC Number:

R446.1

ZHAO Hu. Drug resistance of invasive fungi and its mechanisms[J]. Laboratory Medicine, 2016, 31(9): 735-738.

References 15

1	买佳,王静. 常用抗深部真菌感染药物及真菌对其耐药机制的研究进展[J]. 中国感染与化疗杂志,2015,15(4):395-398.
2	代华,陈木英,陈立宇,等. 深部真菌感染的耐药机制研究进展[J]. 华西医学,2011,26(1):142-145.
3	JENSEN RH,ASTVAD KM,SILVA LV,et al.Stepwise emergence of azole,echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations[J]. J Antimicrob Chemother,2015,70(9):2551-2555.
4	WANG Y,LIU JY,SHI C,et al.Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans[J]. Int J Antimicrob Agents,2015,46(5):552-559.
5	LO HJ,TSENG KY,KAO YY,et al.Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans[J]. Int J Antimicrob Agents,2015,45(6):617-621.
6	TEYMURI M,MAMISHI S,POURAKBARI B,et al.Investigation of ERG11 gene expression among fluconazole-resistant Candida albicans:first report from an Iranian referral paediatric hospital[J]. Br J Biomed Sci,2015,72(1):28-31.
7	MORIO F,PAGNIEZ F,LACROIX C,et al.Amino acid substitutions in the Candida albicans sterol Δ5``2,6-desaturase(Erg3p) confer azole resistance:characterization of two novel mutants with impaired virulence[J]. J Antimicrob Chemother,2012,67(9):2131-2138.
8	NOBILE CJ,NETT JE,ANDES DR,et al.Function of Candida albicans adhesin Hwp1 in biofilm formation[J]. Eukaryot Cell,2006,5(10):1604-1610.
9	FANNING S,XU W,SOLIS N,et al.Divergent targets of Candida albicans biofilm regulator Bcr1 in vitro and in vivo[J]. Eukaryot Cell,2012,11(7):896-904.
10	WALSH TJ,ANAISSIE EJ,DENNING DW,et al.Treatment of aspergillosis:clinical practice guidelines of the Infectious Diseases Society of America[J]. Clin Infect Dis,2008,46(3):327-360.
11	VERMEULEN E,LAGROU K,VERWEIJ PE.Azole resistance in Aspergillus fumigatus:a growing public health concern[J]. Curr Opin Infect Dis,2013,26(6):493-500.
12	VERWEIJ PE,HOWARD SJ,MELCHERS WJ,et al.Azole-resistance in Aspergillus:proposed nomenclature and breakpoints[J]. Drug Resist Updat,2009,12(6):141-147.
13	MITCHELL TG,PERFECT JR.Cryptococcosis in the era of AIDS-100 years after the discovery of Cryptococcus neoformans[J]. Clin Microbiol Rev,1995,8(4):515-548.
14	PERFECT JR,DISMUKES WE,DROMER F,et al.Clinical practice guidelines for the management of cryptococcal disease:2010 update by the infectious diseases society of America[J]. Clin Infect Dis,2010,50(3):291-322.
15	KIRKPATRICK WR,NAJVAR LK,BOCANEGRA R,et al.New guinea pig model of cryptococcal meningitis[J]. Antimicrob Agents Chemother,2007,51(8):3011-3013.

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