Status of clinical application of ionized calcium determination and corrected calcium concentration equation

doi:10.3969/j.issn.1673-8640.2016.07.019

Abstract

Abstract:

Total calcium is consisted of ionized calcium and physiologically inactive calcium（mainly associated with albumin,as well as bicarbonate,citrate and lactate）. Monitoring patients' calcium status is not straightforward, because both ionized and total calcium determinations are commonly available for clinical interpretation,and each has advantages and disadvantages. Total calcium is more convenient to be measured than ionized calcium,and is more frequently used by clinical laboratories. However,total calcium can not represent patients' calcium status correctly in some specific clinical situations. This review focuses on the research status of corrected calcium concentration equation,ionized calcium and total calcium.

Key words: Total calcium, Ionized calcium, Corrected calcium concentration equation

CLC Number:

R446.1

WU Jiong, PAN Baishen. Status of clinical application of ionized calcium determination and corrected calcium concentration equation[J]. Laboratory Medicine, 2016, 31(7): 623-626.

Figures/Tables 1

References 11

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首次报道研究者	首次报道时间	计算公式
Mondified Orell	不详	cCa=tCa+0.8×（4-Alb）
Dent	1962	cCa=tCa-0.675×（TP-7.2）
Parfitt	1969	cCa=tCa/（0.6+0.0541×TP）
Moore	1970	cCa=tCa-4×[0.001 9×Alb-0.42×Alb/473×（7.42-pH）+0.000 4×（TP-Alb）- 0.42×（TP-Alb）/250×（7.42-pH）]
Orrell	1971	cCa=tCa-0.707×（Alb-3.4）
Husdan	1973	cCa=tCa/（0.6+0.051 5×TP）
Berry	1973	cCa=tCa-0.91×（Alb-4.6）
Payne	1973	cCa=tCa-（0.989×Alb）+4
Ryan	1973	cCa=tCa+0.72×（4-Alb）
Pain	1975	cCa=tCa+（4-Alb）
Christiansen	1975	cCa=tCa/（0.6+0.05×TP）
Kelly	1976	cCa=（tCa -6）/0.05×TP
Walker	1979	cCa=tCa+0.92×（4-Alb）
Thode	1989	cCa=tCa×2.7/（1.7+Alb/4.2）
Ferrari*	2009	cCa=tCa+0.015×（40-Alb）+0.07×（1.5-P）
Zeisler	1954	iCa= [6×tCa-TP/3/（TP+6）]/40.08
Hanna	1964	iCa=11.8×t Ca/（11.8+TP）/4
Pottgen	1976	iCa= [6×tCa-（0.19×TP+Alb）/3]/（0.19×TP+Alb+6）
Fenton	1983	iCa=（0.58×tCa-0.28×Alb+2.5）×10/40.08
Forster	1985	iCa= [0.9+（0.55×tCa）-（0.3×Alb）]/4
Nordin	1989	iCa=tCa/4-0.061 3×tCa×Alb-0.024 4×tCa×（TP-Alb）-0.004 3× tCa×AG- 0.003 75×tCa×tCO₂

首次报道研究者	首次报道时间	计算公式
Mondified Orell	不详	cCa=tCa+0.8×（4-Alb）
Dent	1962	cCa=tCa-0.675×（TP-7.2）
Parfitt	1969	cCa=tCa/（0.6+0.0541×TP）
Moore	1970	cCa=tCa-4×[0.001 9×Alb-0.42×Alb/473×（7.42-pH）+0.000 4×（TP-Alb）- 0.42×（TP-Alb）/250×（7.42-pH）]
Orrell	1971	cCa=tCa-0.707×（Alb-3.4）
Husdan	1973	cCa=tCa/（0.6+0.051 5×TP）
Berry	1973	cCa=tCa-0.91×（Alb-4.6）
Payne	1973	cCa=tCa-（0.989×Alb）+4
Ryan	1973	cCa=tCa+0.72×（4-Alb）
Pain	1975	cCa=tCa+（4-Alb）
Christiansen	1975	cCa=tCa/（0.6+0.05×TP）
Kelly	1976	cCa=（tCa -6）/0.05×TP
Walker	1979	cCa=tCa+0.92×（4-Alb）
Thode	1989	cCa=tCa×2.7/（1.7+Alb/4.2）
Ferrari*	2009	cCa=tCa+0.015×（40-Alb）+0.07×（1.5-P）
Zeisler	1954	iCa= [6×tCa-TP/3/（TP+6）]/40.08
Hanna	1964	iCa=11.8×t Ca/（11.8+TP）/4
Pottgen	1976	iCa= [6×tCa-（0.19×TP+Alb）/3]/（0.19×TP+Alb+6）
Fenton	1983	iCa=（0.58×tCa-0.28×Alb+2.5）×10/40.08
Forster	1985	iCa= [0.9+（0.55×tCa）-（0.3×Alb）]/4
Nordin	1989	iCa=tCa/4-0.061 3×tCa×Alb-0.024 4×tCa×（TP-Alb）-0.004 3× tCa×AG- 0.003 75×tCa×tCO₂

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