The significance of the combined detection of AFP and ferritin with serum hepatic fibrosis indices in Child-Pugh classification among patients with liver cirrhosis

Abstract

Abstract:

Objective　To investigate the correlations of serum hepatic fibrosis indices， alpha fetoprotein（AFP） and ferritin with Child-Pugh classification among patients with liver cirrhosis and their significance. Methods　A total of 128 patients with liver cirrhosis were enrolled， including viral hepatitis B（67 cases）， alcoholic liver cirrhosis（48 cases） and viral hepatitis C（13 cases）. Child-Pugh classification of these patients were A（45 cases）， B（49 cases） and C（34 cases）. A total of 50 healthy subjects were enrolled as control group. Venous blood was extracted for serum fibrosis indices， AFP and ferritin determinations. Results　With the severity of liver cirrhosis， Child-Pugh classification increased from A to C， and serum fibrosis， AFP as well as ferritin also gradually increased. There was a significant correlation with Child-Pugh classification. Conclusions　Serum fibrosis indices， AFP and ferritin are all related with the severity of liver cirrhosis. The combined detection has high reference significance for evaluating the severity and prognosis of liver cirrhosis.

Key words: Hepatic fibrosis index, Alpha fetoprotein, Serum ferritin, Liver cirrhosis

CLC Number:

R446.11

WANG Fengyuan, ZHANG Linhua, LAI Weiqiang. The significance of the combined detection of AFP and ferritin with serum hepatic fibrosis indices in Child-Pugh classification among patients with liver cirrhosis[J]. , 2014, 29(12): 1222-1225.

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