Abstract:

Objective To investigate the correlation between angiotensin Ⅱ level and the severity of liver cirrhosis.Methods A total of 122 patients with liver cirrhosis were enrolled as study group,and 122 healthy subjects matched with age and sex were enrolled as control group. The end-stage liver disease model（MELD） and end-stage liver disease model combined with serum sodium（MELD-Na） scores were used to assess the severity of liver cirrhosis. Serum angiotensin Ⅱ levels of the 2 groups were determined.Results Serum angiotensin Ⅱ level in study group was higher than that in control group（P<0.001）. Serum angiotensin Ⅱ level in MELD≥20 group was higher than those in MELD<9 group and MELD 10-19 group（P<0.05）. Correlation analysis showed that there was a positive correlation between serum angiotensin Ⅱ level and MELD score（r=0.563,P<0.001）. Serum angiotensin Ⅱ level with MELD-Na>23 group was higher than that with MELD-Na≤23 group（P<0.01）. There was a positive correlation between serum angiotensin Ⅱ level and MELD-Na score（r=0.621,P<0.001）. Serum angiotensin Ⅱ level in liver cirrhosis patients with ascites was higher than that in liver cirrhosis patients without ascites（P<0.001）.Conclusions In patients with liver cirrhosis,serum angiotensin Ⅱ level is increased and is closely related to the severity of liver cirrhosis.

Key words: Angiotensin Ⅱ, Liver cirrhosis, End-stage liver disease model, End-stage liver disease model combined with serum sodium, Ascites