Significance on the combined detection of human epididymis protein 4 and CYFRA21-1 in the diagnosis of non-small cell lung cancer

Abstract

Abstract:

Objective　To investigate the significance on the combined detection of human epididymis protein 4（HE4） and cytokeratin 19 fragment（CYFRA21-1） in the diagnosis of non-small cell lung cancer（NSCLC）. Methods　The levels of serum HE4 and CYFRA21-1 were detected in 50 NSCLC patients， 40 patients with pneumonia and 50 healthy subjects. The diagnosis significance of the combined detection of serum HE4 and CYFRA21-1 for NSCLC was analyzed by receiver operating characteristic（ROC） curve. Results　The levels of serum CYFRA21-1 and HE4 in all the NSCLC patients and the level of HE4 in patients with Ⅰ-Ⅱ stages of NSCLC were significantly higher than those in pneumonia patients and healthy subjects（P＜0.05）. The levels of serum HE4 and CYFRA21-1 in patients with Ⅲ-Ⅳ stages of NSCLC were significantly higher than those in patients with Ⅰ-Ⅱ stages of NSCLC（P＜0.05）. The sensitivity of the combined detection was high than that of any single detection. Conclusions　The detection of serum HE4 has a high significance for the early diagnosis of NSCLC compared with CYFRA21-1 detection. The combined detection of HE4 and CYFRA21-1 for the diagnosis of NSCLC has a high sensitivity， and is suitable for the clinical screening of lung cancer.

Key words: Human epididymis protein 4, Cytokeratin 19 fragment, Non-small cell lung cancer

CLC Number:

R446.62

ZHANG Ping, ZHOU Hongxing, BAI Yang, HU Yujing, SUN Yingxin, ZHANG Hong. Significance on the combined detection of human epididymis protein 4 and CYFRA21-1 in the diagnosis of non-small cell lung cancer[J]. , 2014, 29(12): 1215-1217.

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