Abstract: Objective To investigate the diagnostic significance on the detections of serum typeⅠpepsinogen(PGⅠ), typeⅡpepsinogen(PGⅡ),PGⅠ/PGⅡratio, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 72-4(CA72-4) for gastric cancer. Methods A total of 40 cases diagnosed as gastric cancer by electronic gastroscope were enrolled for gastric cancer group, 40 cases with superficial gastritis or stomach ulcers were as benign gastric disease group, and 40 healthy subjects were as control group. Serum PGⅠ, PGⅡ, PGⅠ/PGⅡratio, CEA, CA19-9 and CA72-4 were determined quantitatively. The results were analyzed comparatively among the 3 groups. Results The serum levels of PGⅠ, PGⅡ, PGⅠ/PGⅡratio,CEA, CA19-9 and CA72-4 in gastric cancer group were significantly different from those in the other 2 groups (P<0.05) .According to the receiver operating characteristics (ROC) curve, the cut-off value of PGⅠwas 54 ng/mL (sensitivity 63.9%, specificity 79.7%, the area under ROC curve 0.851±0.047). The cut-off value of PGⅠ/PGⅡratio was 4.5(sensitivity 75%,specificity 80.6%, the area under ROC curve 0.788±0.056).The cut-off value of CEA was 3.20 ng/mL (sensitivity 56.4%, specificity 76.9%, the area under ROC curve 0.310±0.063). The cut-off value of CA19-9 was 34.05 U/mL (sensitivity 54.6%, specificity 69.2%, the area under ROC curve 0.352±0.065). The cut-off value of CA72-4 was 3.18 IU/mL (sensitivity 53.8%, specificity 79.5%, the area under ROC curve 0.344±0.065).The sensitivity of the combined detections of PGⅠ,PGⅠ/PGⅡratio,CEA, CA19-9 and CA72-4 (89.4%) was significantly higher than those of the individual detections (P<0.05). Conclusions The levels of serum PGⅠ, PGⅠ/PGⅡratio,CEA, CA19-9 and CA72-4 are very valuable in the diagnosis of gastric cancer. The combined detection helps with improving the positive detection rate of gastric cancer.

Key words: Pepsinogen, Tumor marker, Gastric cancer