Investigation on the detection and its significance of vascular risk factors in the subjects with different blood pressure

doi:10.3969/j.issn.1673-8640.2014.03.013

Abstract

Abstract:

Objective　To detect the vascular risk factors in the subjects with different blood pressure，in order to investigate the significance of vascular risk factors in the diagnosis and prevention of cardiovascular diseases. Methods　A total of 246 subjects were classified into normal blood pressure group（35 cases），normal blood pressure high value group（46 cases），grade 1 hypertension group（52 cases），grade 2 hypertension group（55 cases） and grade 3 hypertension group（58 cases） according to the Guidelines for the Prevention and Treatment of Hypertension in China 2010. Serum endothelin-1（ET-1），high-sensitivity C-reactive protein（hs-CRP） and homocysteine（Hcy） were determined，and the carotid artery intima-media thickness（IMT） was measured by color ultrasound. The difference among the groups was analyzed. Results　The Hcy levels of grade 2 and 3 hypertension groups were higher than those of the other 3 groups（P＜0.05），and the Hcy level of grade 3 hypertension group was higher than that of grade 2 hypertension group（P＜0.05）. The hs-CRP level of grade 3 hypertension group was higher than those of the other 4 groups（P＜0.05），the hs-CRP level of grade 2 hypertension group was higher than those of normal blood pressure and normal blood pressure high value groups（P＜0.05），and the hs-CRP level of grade 1 hypertension group was higher than that of normal blood pressure group（P＜0.05）. The ET-1 levels of grade 1，2 and 3 hypertension groups were higher than those of normal blood pressure and normal blood pressure high value groups（P＜0.05），and the ET-1 levels of grade 1，2 and 3 hypertension groups were significant statistically（P＜0.05）. The IMT detection results of grade 3 hypertension group were higher than those of the other 4 groups（P＜0. 05），and those of grade 2 hypertension group were higher than those of normal blood pressure and normal blood pressure high value groups（P＜0.05）. ET-1，hs-CRP，Hcy and IMT increased with systolic pressure，and the correlation coefficients（r） were 0.302，0.214，0.192 and 0.285（P＜0.05）； ET-1，hs-CRP and Hcy had positive correlations with IMT（r=0.358，0.249 and 0.226，P＜0.05）. Conclusions　There are good correlations among ET-1，hs-CRP and Hcy with IMT and corresponding blood pressure，and the ET-1 is the most sensitive in the progress of blood pressure change. ET-1，hs-CRP，Hcy and IMT should be used as routine physical examination parameters in order to prevent or stop cardiovascular risk. Especially，the subjects with normal blood pressure at present should be paid attention.

Key words: Vascular risk factor, Endothelin-1, Homocysteine, High-sensitivity C-reactive protein, Carotid artery intima-media thickness, Hypertension

CLC Number:

R446.1

WANG Guoqiang, YANG Cailing, GUO Lijuan. Investigation on the detection and its significance of vascular risk factors in the subjects with different blood pressure[J]. , 2014, 29(3): 254-257.

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