Abstract: Objective　To investigate the diagnostic value of serum carcinoembryonic antigen (CEA)， carbohydrate antigen 72-4 (CA72-4) and pepsinogen (PG) combined determination for gastric cancer.  Methods　Serum CEA，CA72-4，PGⅠ，PGⅡ and PGⅠ/Ⅱ were detected in 96 healthy controls，37 gastric hyperplasia patients and 107 gastric cancer patients. Results　When the CA72-4，CEA，PGⅠ，PGⅡand PGⅠ/Ⅱ were used to diagnose gastric hyperplasia and gastric cancer individually，CA72-4 had the best diagnostic capability. Its sensitivity and specificity were 72.00% and 59.50%. Binary logistic regression was used to evaluate the diagnostic value of combining CEA and CA72-4 to diagnose the gastric hyperplasia and gastric cancer. The area under the curve was 0.715， and the sensitivity and specificity were 70.10% and 67.60%. Compared to the sensitivity and specificity of each marker， the sensitivity and specificity of combined determination with 3 markers were better. Multilayer perceptron neural network analysis was also used to analyze the diagnostic value of CEA and CA72-4 combined determination. The area under the curve was 0.711. Conclusions　The diagnostic value of the combined determination is superior， and it also provides reference for the clinical diagnosis of gastric cancer.

Key words:  Gastric cancer, Carcinoembryonic antigen, Carbohydrate antigen 72-4, Pepsinogen,  , Gastric cancer, Carcinoembryonic antigen, Carbohydrate antigen 72-4, Pepsinogen