Research progress of Streptococcus pneumoniae

doi:10.3969/j.issn.1673-8640.2026.02.017

Abstract

Abstract:

Streptococcus pneumoniae（Sp） can cause community-acquired infection，it is the first opportunistic pathogen of out-of-hospital infection，and it is an important pathogen causing community-acquired pneumonia（CAP）. Sp infection can cause pneumonia，otitis media，meningitis，bloodstream infection and other diseases. The pathogenic mechanism of Sp is mainly related to capsular polysaccharide（CPS），hemolysin，protease，biofilm，hydrogen peroxide and so on. At present，with the widespread application of broad-spectrum antimicrobials and immune agents and the increase of penicillin-resistant and multi-drug resistant isolates，the drug resistance is becoming increasingly serious. The main reason for Sp drug resistance is the mutation of penicillin-binding protein（PBP），which causes great obstacles to clinical diagnosis and treatment. For the antimicrobial treatment of Sp infection，penicillin is recommended as the first choice. The review focuses on the research progress of Streptococcus pneumoniae.

Key words: Streptococcus pneumoniae, Pathogenic mechanism, Drug resistance

CLC Number:

R378.1

YANG Chengfan, HAN Liang, LI Weixia, SHI Jian, LI Xue, LU Shuhua. Research progress of Streptococcus pneumoniae[J]. Laboratory Medicine, 2026, 41(2): 196-201.

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