Abstract:

Objective To investigate the application role of fecal calprotectin（FC）in the disease status assessment and treatment efficiency monitoring of children with inflammatory bowel disease（IBD）. Methods From March 2021 to December 2024，118 children with IBD（IBD group）and 35 healthy subjects（healthy control group） were enrolled from the Children's Hospital of Fudan University. The FC levels were determined. According to the simple endoscopic score for Crohn's disease（SES-CD）and ulcerative colitis Mayo score（UCMS），the subjects were classified into remission group（32 cases），mild active group（45 cases），moderate active group（75 cases）and severe active group（84 cases）. The follow-up was compared with the colonoscopy results before and after treatment. According to whether the disease activity was reduced，they were classified into activity reduction group（53 cases）and activity non-reduction group（65 cases）. Spearman correlation analysis was used to evaluate the correlation between FC level and colonoscopy results. Results The FC level of IBD group was higher than that of healthy control group（P<0.05）. The FC level was positively correlated with the degree of disease activity（r=0.572，P<0.05）. The FC levels of remission group，mild active group，moderate active group and severe active group were gradually increased（P<0.05）. The FC level after treatment in activity reduction group was lower than that before treatment（P<0.05）. Conclusions The FC level of IBD children is high，and the FC level is correlated with colonoscopy results，which is beneficial for the disease status assessment and treatment efficiency monitoring of children with inflammatory bowel disease and has good clinical application value.

Key words: Calprotectin, Feces, Inflammatory bowel disease, Ulcerative colitis, Crohn's disease