Research progress of serological biomarkers for inflammatory bowel disease

doi:10.3969/j.issn.1673-8640.2018.02.016

Abstract

Abstract:

Inflammatory bowel disease（IBD）,including Crohn's disease（CD） and ulcerative colitis（UC）,is a chronic intestinal inflammation of unknown etiology. At present,the diagnosis of IBD is confirmed mainly by endoscopy and histopathologic examination of biopsies,and the invasiveness and difficult operations of such inspections make it necessary to find a non-invasive method that is more convenient,sensitive,affordable and efficient. Serological biomarkers may meet this demand and has become a focus of IBD research. This review summarizes recent research progress in the field of IBD,advance in traditional markers and some new types of markers such as anti-glycoprotein 2（GP2） antibody,anti-CUB and zona pellucida-like domain-containing protein 1（CUZD1） antibody,apoptosis inhibitor of macrophage（AIM） and serum-derived hyaluronan-associated protein（SAHP）.

Key words: Serological biomarker, Inflammatory bowel disease, Ulcerative colitis, Crohn's disease

CLC Number:

R446.62

ZENG Junxiang, PAN Xiujun, SHEN Lisong. Research progress of serological biomarkers for inflammatory bowel disease[J]. Laboratory Medicine, 2018, 33(2): 170-176.

Figures/Tables 1

References 31

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标志物	可能的靶抗原	阳性率			临床意义
		CD（%）	UC（%）	对照（%）	诊断/鉴别诊断	疾病表型/风险评估	预后/疗效评估	探究发病机制	指导治疗	参考
		CD（%）	UC（%）	对照（%）	诊断/鉴别诊断	疾病表型/风险评估	预后/疗效评估	探究发病机制	指导治疗	文献
ap-ANCA	中性粒细胞胞浆	2~28	45~82	<5	+	-	-	+	-	[6]
ap-ANCA	成分	2~28	45~82	<5	+	-	-	+	-	[6]
抗HMGB1	高迁移率族蛋白	27~34	2~24	0	-	+	-	+	-	[8]
抗体	B1	27~34	2~24	0	-	+	-	+	-	[8]
抗GP2抗体	PG2	0~45	2~12	1~8	+	-	-	+	-	[13]
抗CUZD1	人CUZD1	20.8~26.0								[15]
抗体	人CUZD1	20.8~26.0								[15]
GAB	小肠上皮杯状细胞	2~33	16~46	0	+	-	-	-	-	[16]
抗GM-CSF	GM-CSF				-	+	-	+	-	[19]
抗体	GM-CSF				-	+	-	+	-	[19]
ASCA	酿酒酵母细胞壁上	50~80	5~15	1~7	+	-	-	+	-	[22]
ASCA	磷酸肽甘露聚糖的甘露糖序列	50~80	5~15	1~7	+	-	-	+	-	[22]
ALCA	β-1-3多聚糖家族	20~25	4~9	2~12	+	+	-	-	+	[22]
ALCA	中“昆布多糖”	20~25	4~9	2~12	+	+	-	-	+	[22]
ACCA	N-乙酰-β-D 氨基	9~27	3~7	4~12	+	+	-	-	+	[22]
	葡糖聚合物“壳
	质”构的主要成
	成分之一
AMCA	甘露二糖	12~27	3~7	4~12	+	+	-	-	+	[22]
anti-L	昆布多糖	18~26	3~7	1~10	+	-	-	-	-	[22]
anti-C	壳质多糖	10~25	3~11	2~12						[22]
抗OmpC	大肠埃希菌外膜孔道C转运蛋白	24~55	2~24	0~5	+	+	-	+	-	[25]
抗体	大肠埃希菌外膜孔道C转运蛋白	24~55	2~24	0~5	+	+	-	+	-	[25]
抗I2抗体	荧光假单胞菌相关	38~60	2~10	4~8	+	+	+	-	+	[26]
抗I2抗体	序列I2	38~60	2~10	4~8	+	+	+	-	+	[26]
抗CBir1	细菌鞭毛蛋白CBir1	50~57	6~16	8~15	-	+	-	-	-	[27]
抗体	细菌鞭毛蛋白CBir1	50~57	6~16	8~15	-	+	-	-	-	[27]
抗A4-Fla2	细菌鞭毛蛋白A4-	59	6		-	-	-	-	-	[23]
抗体	Fla2	59	6		-	-	-	-	-	[23]
抗Fla-X	细菌鞭毛蛋白Fla-X	57	6
抗体	细菌鞭毛蛋白Fla-X	57	6
抗MAP	MAP	46~64	33~39	3~10	+	-	-	-	+	[29]
抗体	MAP	46~64	33~39	3~10	+	-	-	-	+	[29]
AIM		76.3			+	-	-	-	-	[30]
SHAP					-	-	+	-	-	[31]

标志物	可能的靶抗原	阳性率			临床意义
		CD（%）	UC（%）	对照（%）	诊断/鉴别诊断	疾病表型/风险评估	预后/疗效评估	探究发病机制	指导治疗	参考
		CD（%）	UC（%）	对照（%）	诊断/鉴别诊断	疾病表型/风险评估	预后/疗效评估	探究发病机制	指导治疗	文献
ap-ANCA	中性粒细胞胞浆	2~28	45~82	<5	+	-	-	+	-	[6]
ap-ANCA	成分	2~28	45~82	<5	+	-	-	+	-	[6]
抗HMGB1	高迁移率族蛋白	27~34	2~24	0	-	+	-	+	-	[8]
抗体	B1	27~34	2~24	0	-	+	-	+	-	[8]
抗GP2抗体	PG2	0~45	2~12	1~8	+	-	-	+	-	[13]
抗CUZD1	人CUZD1	20.8~26.0								[15]
抗体	人CUZD1	20.8~26.0								[15]
GAB	小肠上皮杯状细胞	2~33	16~46	0	+	-	-	-	-	[16]
抗GM-CSF	GM-CSF				-	+	-	+	-	[19]
抗体	GM-CSF				-	+	-	+	-	[19]
ASCA	酿酒酵母细胞壁上	50~80	5~15	1~7	+	-	-	+	-	[22]
ASCA	磷酸肽甘露聚糖的甘露糖序列	50~80	5~15	1~7	+	-	-	+	-	[22]
ALCA	β-1-3多聚糖家族	20~25	4~9	2~12	+	+	-	-	+	[22]
ALCA	中“昆布多糖”	20~25	4~9	2~12	+	+	-	-	+	[22]
ACCA	N-乙酰-β-D 氨基	9~27	3~7	4~12	+	+	-	-	+	[22]
	葡糖聚合物“壳
	质”构的主要成
	成分之一
AMCA	甘露二糖	12~27	3~7	4~12	+	+	-	-	+	[22]
anti-L	昆布多糖	18~26	3~7	1~10	+	-	-	-	-	[22]
anti-C	壳质多糖	10~25	3~11	2~12						[22]
抗OmpC	大肠埃希菌外膜孔道C转运蛋白	24~55	2~24	0~5	+	+	-	+	-	[25]
抗体	大肠埃希菌外膜孔道C转运蛋白	24~55	2~24	0~5	+	+	-	+	-	[25]
抗I2抗体	荧光假单胞菌相关	38~60	2~10	4~8	+	+	+	-	+	[26]
抗I2抗体	序列I2	38~60	2~10	4~8	+	+	+	-	+	[26]
抗CBir1	细菌鞭毛蛋白CBir1	50~57	6~16	8~15	-	+	-	-	-	[27]
抗体	细菌鞭毛蛋白CBir1	50~57	6~16	8~15	-	+	-	-	-	[27]
抗A4-Fla2	细菌鞭毛蛋白A4-	59	6		-	-	-	-	-	[23]
抗体	Fla2	59	6		-	-	-	-	-	[23]
抗Fla-X	细菌鞭毛蛋白Fla-X	57	6
抗体	细菌鞭毛蛋白Fla-X	57	6
抗MAP	MAP	46~64	33~39	3~10	+	-	-	-	+	[29]
抗体	MAP	46~64	33~39	3~10	+	-	-	-	+	[29]
AIM		76.3			+	-	-	-	-	[30]
SHAP					-	-	+	-	-	[31]